A nested case-control study of stomach cancer incidence and serum superoxide dismutase activity in the Japan Collaborative Cohort study in Japan

Truong Minh Pham, Yoshihisa Fujino, Shogo Kikuchi, Akiko Tamakoshi, Hiroshi Yatsuya, Tatsuhiko Kubo, Shinya Matsuda, Takesumi Yoshimura

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: We conducted a nested case-control study to investigate the association between serum levels of superoxide dismutase (SOD) enzyme and the incidence of stomach cancer. Methods: A nested case-control study was established within the Japan Collaborative Cohort Study. The follow-up period was from 1988 through 1997. Newly diagnosed cases of stomach cancer were recorded in 804 subjects, of these sera were available for 161 cases. Each of these cases was matched on study area, gender and baseline age with two controls; giving 161 stomach cancer cases and 314 control subjects for analysis. Serum levels of SODs were divided into quartiles, with the first quartile used as the reference. Odds ratios (ORs) and 95% confidence interval (95% CI) for the other serum level quartiles were estimated using the conditional logistic model. Results: The adjusted ORs and 95% CI for the second, third, and fourth SOD quartiles were 0.71 (95% CI: 0.42-1.19), 0.59 (95% CI: 0.32-1.10), and 0.86 (95% CI: 0.48-1.54), respectively. Conclusion: We found no association between SOD serum level and the risk of stomach cancer. The role of SOD in the development of stomach cancer requires further investigation.

Original languageEnglish
Pages (from-to)431-435
Number of pages5
JournalCancer Detection and Prevention
Volume31
Issue number6
DOIs
Publication statusPublished - 06-12-2007
Externally publishedYes

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Superoxide Dismutase
Stomach Neoplasms
Case-Control Studies
Japan
Cohort Studies
Confidence Intervals
Incidence
Serum
Odds Ratio
Logistic Models
Enzymes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Pham, Truong Minh ; Fujino, Yoshihisa ; Kikuchi, Shogo ; Tamakoshi, Akiko ; Yatsuya, Hiroshi ; Kubo, Tatsuhiko ; Matsuda, Shinya ; Yoshimura, Takesumi. / A nested case-control study of stomach cancer incidence and serum superoxide dismutase activity in the Japan Collaborative Cohort study in Japan. In: Cancer Detection and Prevention. 2007 ; Vol. 31, No. 6. pp. 431-435.
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abstract = "Background: We conducted a nested case-control study to investigate the association between serum levels of superoxide dismutase (SOD) enzyme and the incidence of stomach cancer. Methods: A nested case-control study was established within the Japan Collaborative Cohort Study. The follow-up period was from 1988 through 1997. Newly diagnosed cases of stomach cancer were recorded in 804 subjects, of these sera were available for 161 cases. Each of these cases was matched on study area, gender and baseline age with two controls; giving 161 stomach cancer cases and 314 control subjects for analysis. Serum levels of SODs were divided into quartiles, with the first quartile used as the reference. Odds ratios (ORs) and 95{\%} confidence interval (95{\%} CI) for the other serum level quartiles were estimated using the conditional logistic model. Results: The adjusted ORs and 95{\%} CI for the second, third, and fourth SOD quartiles were 0.71 (95{\%} CI: 0.42-1.19), 0.59 (95{\%} CI: 0.32-1.10), and 0.86 (95{\%} CI: 0.48-1.54), respectively. Conclusion: We found no association between SOD serum level and the risk of stomach cancer. The role of SOD in the development of stomach cancer requires further investigation.",
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A nested case-control study of stomach cancer incidence and serum superoxide dismutase activity in the Japan Collaborative Cohort study in Japan. / Pham, Truong Minh; Fujino, Yoshihisa; Kikuchi, Shogo; Tamakoshi, Akiko; Yatsuya, Hiroshi; Kubo, Tatsuhiko; Matsuda, Shinya; Yoshimura, Takesumi.

In: Cancer Detection and Prevention, Vol. 31, No. 6, 06.12.2007, p. 431-435.

Research output: Contribution to journalArticle

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T1 - A nested case-control study of stomach cancer incidence and serum superoxide dismutase activity in the Japan Collaborative Cohort study in Japan

AU - Pham, Truong Minh

AU - Fujino, Yoshihisa

AU - Kikuchi, Shogo

AU - Tamakoshi, Akiko

AU - Yatsuya, Hiroshi

AU - Kubo, Tatsuhiko

AU - Matsuda, Shinya

AU - Yoshimura, Takesumi

PY - 2007/12/6

Y1 - 2007/12/6

N2 - Background: We conducted a nested case-control study to investigate the association between serum levels of superoxide dismutase (SOD) enzyme and the incidence of stomach cancer. Methods: A nested case-control study was established within the Japan Collaborative Cohort Study. The follow-up period was from 1988 through 1997. Newly diagnosed cases of stomach cancer were recorded in 804 subjects, of these sera were available for 161 cases. Each of these cases was matched on study area, gender and baseline age with two controls; giving 161 stomach cancer cases and 314 control subjects for analysis. Serum levels of SODs were divided into quartiles, with the first quartile used as the reference. Odds ratios (ORs) and 95% confidence interval (95% CI) for the other serum level quartiles were estimated using the conditional logistic model. Results: The adjusted ORs and 95% CI for the second, third, and fourth SOD quartiles were 0.71 (95% CI: 0.42-1.19), 0.59 (95% CI: 0.32-1.10), and 0.86 (95% CI: 0.48-1.54), respectively. Conclusion: We found no association between SOD serum level and the risk of stomach cancer. The role of SOD in the development of stomach cancer requires further investigation.

AB - Background: We conducted a nested case-control study to investigate the association between serum levels of superoxide dismutase (SOD) enzyme and the incidence of stomach cancer. Methods: A nested case-control study was established within the Japan Collaborative Cohort Study. The follow-up period was from 1988 through 1997. Newly diagnosed cases of stomach cancer were recorded in 804 subjects, of these sera were available for 161 cases. Each of these cases was matched on study area, gender and baseline age with two controls; giving 161 stomach cancer cases and 314 control subjects for analysis. Serum levels of SODs were divided into quartiles, with the first quartile used as the reference. Odds ratios (ORs) and 95% confidence interval (95% CI) for the other serum level quartiles were estimated using the conditional logistic model. Results: The adjusted ORs and 95% CI for the second, third, and fourth SOD quartiles were 0.71 (95% CI: 0.42-1.19), 0.59 (95% CI: 0.32-1.10), and 0.86 (95% CI: 0.48-1.54), respectively. Conclusion: We found no association between SOD serum level and the risk of stomach cancer. The role of SOD in the development of stomach cancer requires further investigation.

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