TY - JOUR
T1 - A nested case-control study of stomach cancer incidence and serum superoxide dismutase activity in the Japan Collaborative Cohort study in Japan
AU - Pham, Truong Minh
AU - Fujino, Yoshihisa
AU - Kikuchi, Shogo
AU - Tamakoshi, Akiko
AU - Yatsuya, Hiroshi
AU - Kubo, Tatsuhiko
AU - Matsuda, Shinya
AU - Yoshimura, Takesumi
N1 - Funding Information:
This work was supported by a Grant-in-Aid for Scientific Research on Priority Areas (2) (No. 12218237) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan. The JACC Study was also supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture of Japan (Monbusho) (Nos. 61010076, 62010074, 63010074, 1010068, 2151065, 3151064, 4151063, 5151069, 6279102, and 11181101).
Funding Information:
The authors express their sincere appreciation to Dr. Kunio Aoki, Professor Emeritus, Nagoya University School of Medicine and former chairman of the JACC Study; Dr. Haruo Sugano, former director of the Cancer Institute, Tokyo, who greatly contributed to the initiation of the JACC Study; and Dr. Yoshiyuki Ohno, Professor Emeritus, Nagoya University School of Medicine, who is past chairman of the study. The authors also wish to thank Dr. Tomoyuki Kitagawa, Cancer Institute of the Japanese Foundation for Cancer Research and former chairman of the Grant-in-Aid for Scientific Research on Priority Area ‘Cancer’, for his full support of this study.
PY - 2007
Y1 - 2007
N2 - Background: We conducted a nested case-control study to investigate the association between serum levels of superoxide dismutase (SOD) enzyme and the incidence of stomach cancer. Methods: A nested case-control study was established within the Japan Collaborative Cohort Study. The follow-up period was from 1988 through 1997. Newly diagnosed cases of stomach cancer were recorded in 804 subjects, of these sera were available for 161 cases. Each of these cases was matched on study area, gender and baseline age with two controls; giving 161 stomach cancer cases and 314 control subjects for analysis. Serum levels of SODs were divided into quartiles, with the first quartile used as the reference. Odds ratios (ORs) and 95% confidence interval (95% CI) for the other serum level quartiles were estimated using the conditional logistic model. Results: The adjusted ORs and 95% CI for the second, third, and fourth SOD quartiles were 0.71 (95% CI: 0.42-1.19), 0.59 (95% CI: 0.32-1.10), and 0.86 (95% CI: 0.48-1.54), respectively. Conclusion: We found no association between SOD serum level and the risk of stomach cancer. The role of SOD in the development of stomach cancer requires further investigation.
AB - Background: We conducted a nested case-control study to investigate the association between serum levels of superoxide dismutase (SOD) enzyme and the incidence of stomach cancer. Methods: A nested case-control study was established within the Japan Collaborative Cohort Study. The follow-up period was from 1988 through 1997. Newly diagnosed cases of stomach cancer were recorded in 804 subjects, of these sera were available for 161 cases. Each of these cases was matched on study area, gender and baseline age with two controls; giving 161 stomach cancer cases and 314 control subjects for analysis. Serum levels of SODs were divided into quartiles, with the first quartile used as the reference. Odds ratios (ORs) and 95% confidence interval (95% CI) for the other serum level quartiles were estimated using the conditional logistic model. Results: The adjusted ORs and 95% CI for the second, third, and fourth SOD quartiles were 0.71 (95% CI: 0.42-1.19), 0.59 (95% CI: 0.32-1.10), and 0.86 (95% CI: 0.48-1.54), respectively. Conclusion: We found no association between SOD serum level and the risk of stomach cancer. The role of SOD in the development of stomach cancer requires further investigation.
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U2 - 10.1016/j.cdp.2007.10.012
DO - 10.1016/j.cdp.2007.10.012
M3 - Article
C2 - 18061374
AN - SCOPUS:36549052152
SN - 0361-090X
VL - 31
SP - 431
EP - 435
JO - Cancer Detection and Prevention
JF - Cancer Detection and Prevention
IS - 6
ER -
