A New Compound (Az36041) Promotes the Survival of the Neurons and Reduces Neurotoxicity of Alzheimer's Beta-Amyloid Protein

Yasushi Hasegawa, Emika Sugimoto, Tomoko Endo, Kohei Ogawa, Anri Morikawa, Hisashi Aratake, Nobuya Kitaguchi, Yasushi Hasegawa, Tomoko Endo

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Alzheimer's β-amyloid protein (Aβ) is the main component of senile plaques, which are characteristic hallmarks of the Alzheimer's disease brain. Recently, there have been several reports that Aβ has toxic effects on both cultured neurons and in the brain. We confirmed the neurotoxicity of Aβ in vitro and found a new compound, called AZ36041 (4-chloro-N-(5-nitro-2-tiazoyl) benzenesulfone amide), which dramatically reduced Aβ neurotoxicity. This compound was also found to have a neuroprotective effect against toxicity of glutamate and enhanced neuronal survival in the absence of neurotoxic compounds. AZ36041 may be a useful tool for investigating the mechanism of Aβ neurotoxicity in vitro and in vivo.

Original languageEnglish
Pages (from-to)1750-1754
Number of pages5
JournalBiological and Pharmaceutical Bulletin
Volume18
Issue number12
DOIs
Publication statusPublished - 01-01-1995

Fingerprint

Amyloid beta-Peptides
Neurons
Serum Amyloid A Protein
Poisons
Amyloid Plaques
Brain
Neuroprotective Agents
Amides
Glutamic Acid
Alzheimer Disease
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

Cite this

Hasegawa, Yasushi ; Sugimoto, Emika ; Endo, Tomoko ; Ogawa, Kohei ; Morikawa, Anri ; Aratake, Hisashi ; Kitaguchi, Nobuya ; Hasegawa, Yasushi ; Endo, Tomoko. / A New Compound (Az36041) Promotes the Survival of the Neurons and Reduces Neurotoxicity of Alzheimer's Beta-Amyloid Protein. In: Biological and Pharmaceutical Bulletin. 1995 ; Vol. 18, No. 12. pp. 1750-1754.
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A New Compound (Az36041) Promotes the Survival of the Neurons and Reduces Neurotoxicity of Alzheimer's Beta-Amyloid Protein. / Hasegawa, Yasushi; Sugimoto, Emika; Endo, Tomoko; Ogawa, Kohei; Morikawa, Anri; Aratake, Hisashi; Kitaguchi, Nobuya; Hasegawa, Yasushi; Endo, Tomoko.

In: Biological and Pharmaceutical Bulletin, Vol. 18, No. 12, 01.01.1995, p. 1750-1754.

Research output: Contribution to journalArticle

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