A new index for non-invasive assessment of liver fibrosis

Naohiro Ichino, Keisuke Osakabe, Toru Nishikawa, Hiroko Sugiyama, Miho Kato, Shiho Kitahara, Senju Hashimoto, Naoto Kawabe, Masao Harata, Yoshifumi Nitta, Michihito Murao, Takuji Nakano, Yuko Arima, Hiroaki Shimazaki, Koji Suzuki, Kentaro Yoshioka

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

AIM: To construct and evaluate a new non-invasive fibrosis index for assessment of the stage of liver fibrosis. METHODS: A new fibrosis index (Fibro-Stiffness index) was developed in 165 of 285 patients with chronic hepatitis C, and was validated in the other 120 patients where liver biopsy was performed. Its usefulness was compared with liver stiffness (LS) measured by FibroScan, the aminotransferase-to-platelet ratio index, the Forns index and the FibroIndex. RESULTS: The Fibro-Stiffness index consists of LS, platelet count and prothrombin time. The values of the Fibro-Stiffness index differed significantly between neighboring fibrosis stages except F0-F1. The area under the receiver operating characteristics curves of the Fibro-Stiffness index for prediction of F ≥ 2 (0.90), F ≥ 3 (0.90) and F = 4 (0.92) in the estimation group and those for F ≥ 3 (0.93) and F = 4 (0.97) in the validation group were the highest among the 5 methods examined. The accuracy of the Fibro-Stiffness index had highest values for F ≥ 2, F ≥ 3 and F = 4 in both the estimation and validation groups. The diagnostic performance for F = 4 was improved by a combination of the Fibro-Stiffness index with serum hyaluronic acid level. CONCLUSION: The Fibro-Stiffness index was constructed and validated. It showed superior diagnostic performance to other indices for F ≥ 2, 3 and 4.

Original languageEnglish
Pages (from-to)4809-4816
Number of pages8
JournalWorld Journal of Gastroenterology
Volume16
Issue number38
DOIs
Publication statusPublished - 14-10-2010

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Liver Cirrhosis
Fibrosis
Liver
Prothrombin Time
Chronic Hepatitis C
Hyaluronic Acid
Transaminases
Platelet Count
ROC Curve
Blood Platelets
Biopsy
F 4
Serum

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Ichino, N., Osakabe, K., Nishikawa, T., Sugiyama, H., Kato, M., Kitahara, S., ... Yoshioka, K. (2010). A new index for non-invasive assessment of liver fibrosis. World Journal of Gastroenterology, 16(38), 4809-4816. https://doi.org/10.3748/wjg.v16.i38.4809
Ichino, Naohiro ; Osakabe, Keisuke ; Nishikawa, Toru ; Sugiyama, Hiroko ; Kato, Miho ; Kitahara, Shiho ; Hashimoto, Senju ; Kawabe, Naoto ; Harata, Masao ; Nitta, Yoshifumi ; Murao, Michihito ; Nakano, Takuji ; Arima, Yuko ; Shimazaki, Hiroaki ; Suzuki, Koji ; Yoshioka, Kentaro. / A new index for non-invasive assessment of liver fibrosis. In: World Journal of Gastroenterology. 2010 ; Vol. 16, No. 38. pp. 4809-4816.
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Ichino, N, Osakabe, K, Nishikawa, T, Sugiyama, H, Kato, M, Kitahara, S, Hashimoto, S, Kawabe, N, Harata, M, Nitta, Y, Murao, M, Nakano, T, Arima, Y, Shimazaki, H, Suzuki, K & Yoshioka, K 2010, 'A new index for non-invasive assessment of liver fibrosis', World Journal of Gastroenterology, vol. 16, no. 38, pp. 4809-4816. https://doi.org/10.3748/wjg.v16.i38.4809

A new index for non-invasive assessment of liver fibrosis. / Ichino, Naohiro; Osakabe, Keisuke; Nishikawa, Toru; Sugiyama, Hiroko; Kato, Miho; Kitahara, Shiho; Hashimoto, Senju; Kawabe, Naoto; Harata, Masao; Nitta, Yoshifumi; Murao, Michihito; Nakano, Takuji; Arima, Yuko; Shimazaki, Hiroaki; Suzuki, Koji; Yoshioka, Kentaro.

In: World Journal of Gastroenterology, Vol. 16, No. 38, 14.10.2010, p. 4809-4816.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A new index for non-invasive assessment of liver fibrosis

AU - Ichino, Naohiro

AU - Osakabe, Keisuke

AU - Nishikawa, Toru

AU - Sugiyama, Hiroko

AU - Kato, Miho

AU - Kitahara, Shiho

AU - Hashimoto, Senju

AU - Kawabe, Naoto

AU - Harata, Masao

AU - Nitta, Yoshifumi

AU - Murao, Michihito

AU - Nakano, Takuji

AU - Arima, Yuko

AU - Shimazaki, Hiroaki

AU - Suzuki, Koji

AU - Yoshioka, Kentaro

PY - 2010/10/14

Y1 - 2010/10/14

N2 - AIM: To construct and evaluate a new non-invasive fibrosis index for assessment of the stage of liver fibrosis. METHODS: A new fibrosis index (Fibro-Stiffness index) was developed in 165 of 285 patients with chronic hepatitis C, and was validated in the other 120 patients where liver biopsy was performed. Its usefulness was compared with liver stiffness (LS) measured by FibroScan, the aminotransferase-to-platelet ratio index, the Forns index and the FibroIndex. RESULTS: The Fibro-Stiffness index consists of LS, platelet count and prothrombin time. The values of the Fibro-Stiffness index differed significantly between neighboring fibrosis stages except F0-F1. The area under the receiver operating characteristics curves of the Fibro-Stiffness index for prediction of F ≥ 2 (0.90), F ≥ 3 (0.90) and F = 4 (0.92) in the estimation group and those for F ≥ 3 (0.93) and F = 4 (0.97) in the validation group were the highest among the 5 methods examined. The accuracy of the Fibro-Stiffness index had highest values for F ≥ 2, F ≥ 3 and F = 4 in both the estimation and validation groups. The diagnostic performance for F = 4 was improved by a combination of the Fibro-Stiffness index with serum hyaluronic acid level. CONCLUSION: The Fibro-Stiffness index was constructed and validated. It showed superior diagnostic performance to other indices for F ≥ 2, 3 and 4.

AB - AIM: To construct and evaluate a new non-invasive fibrosis index for assessment of the stage of liver fibrosis. METHODS: A new fibrosis index (Fibro-Stiffness index) was developed in 165 of 285 patients with chronic hepatitis C, and was validated in the other 120 patients where liver biopsy was performed. Its usefulness was compared with liver stiffness (LS) measured by FibroScan, the aminotransferase-to-platelet ratio index, the Forns index and the FibroIndex. RESULTS: The Fibro-Stiffness index consists of LS, platelet count and prothrombin time. The values of the Fibro-Stiffness index differed significantly between neighboring fibrosis stages except F0-F1. The area under the receiver operating characteristics curves of the Fibro-Stiffness index for prediction of F ≥ 2 (0.90), F ≥ 3 (0.90) and F = 4 (0.92) in the estimation group and those for F ≥ 3 (0.93) and F = 4 (0.97) in the validation group were the highest among the 5 methods examined. The accuracy of the Fibro-Stiffness index had highest values for F ≥ 2, F ≥ 3 and F = 4 in both the estimation and validation groups. The diagnostic performance for F = 4 was improved by a combination of the Fibro-Stiffness index with serum hyaluronic acid level. CONCLUSION: The Fibro-Stiffness index was constructed and validated. It showed superior diagnostic performance to other indices for F ≥ 2, 3 and 4.

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