A new paradigm for hematopoietic cell lineages: revision of the classical concept of the myeloid-lymphoid dichotomy

Hiroshi Kawamoto, Yoshimoto Katsura

Research output: Contribution to journalReview articlepeer-review

83 Citations (Scopus)

Abstract

The concept that blood cells arising from hematopoietic stem cells (HSC) can be subdivided into two major lineages, a myelo-erythroid and a lymphoid lineage, has long persisted. Indeed, it has become almost axiomatic that the first branch point from the HSC produces two progenitors, one for myelo-erythroid cells and the other for lymphoid cells. However, recent studies have provided a battery of findings that cannot be explained by this classical model. We will outline how this classical model arose before describing how we came to propose an alternative 'myeloid-based model', in which myeloid potential is retained in erythroid, T, and B cell branches even after these lineages have segregated from each other.

Original languageEnglish
Pages (from-to)193-200
Number of pages8
JournalTrends in Immunology
Volume30
Issue number5
DOIs
Publication statusPublished - 05-2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Fingerprint

Dive into the research topics of 'A new paradigm for hematopoietic cell lineages: revision of the classical concept of the myeloid-lymphoid dichotomy'. Together they form a unique fingerprint.

Cite this