TY - JOUR
T1 - A new splicing variant for human tyrosine hydroxylase in the adrenal medulla
AU - Ohye, Tamae
AU - Ichinose, Hiroshi
AU - Yoshizawa, Toshihiro
AU - Kanazawa, Ichiro
AU - Nagatsu, Toshiharu
N1 - Funding Information:
This work was supported by Health Science Grants, Research on Brain Science from the Ministry of Health and Welfare of Japan (to T.N.), and by a Grant-in-Aid for Scientific Research on Priority Areas from the Ministry of Education, Science, Sports and Culture of Japan (to T.N.).
PY - 2001/10/26
Y1 - 2001/10/26
N2 - It has been reported that several mRNA isoforms of tyrosine 3-monooxygenase (tyrosine hydroxylase; TH) occur only in primates. New TH isoforms produced by skipping of exon 3 in the adrenal medulla of patients with progressive supranuclear palsy (PSP) have recently been reported, J. Neurochem. 67 (1996) 19. Here, we looked for the presence of new TH isoforms in control brains and adrenal medulla and in brains from patients with PSP. We found a novel type of TH mRNA in the adrenal medulla from one of the control subjects. The mRNA lacked exon 4, resulting in a premature stop codon at amino acid 147. This result suggests the importance of alternative splicing in the regulation of TH activity.
AB - It has been reported that several mRNA isoforms of tyrosine 3-monooxygenase (tyrosine hydroxylase; TH) occur only in primates. New TH isoforms produced by skipping of exon 3 in the adrenal medulla of patients with progressive supranuclear palsy (PSP) have recently been reported, J. Neurochem. 67 (1996) 19. Here, we looked for the presence of new TH isoforms in control brains and adrenal medulla and in brains from patients with PSP. We found a novel type of TH mRNA in the adrenal medulla from one of the control subjects. The mRNA lacked exon 4, resulting in a premature stop codon at amino acid 147. This result suggests the importance of alternative splicing in the regulation of TH activity.
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U2 - 10.1016/S0304-3940(01)02210-8
DO - 10.1016/S0304-3940(01)02210-8
M3 - Article
C2 - 11602334
AN - SCOPUS:0035955489
VL - 312
SP - 157
EP - 160
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 3
ER -