A new splicing variant for human tyrosine hydroxylase in the adrenal medulla

Tamae Ohye; Hiroshi Ichinose; Toshihiro Yoshizawa; Ichiro Kanazawa; Toshiharu Nagatsu

doi:10.1016/S0304-3940(01)02210-8

A new splicing variant for human tyrosine hydroxylase in the adrenal medulla

Tamae Ohye, Hiroshi Ichinose, Toshihiro Yoshizawa, Ichiro Kanazawa, Toshiharu Nagatsu

Faculty of Medical Technology

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

It has been reported that several mRNA isoforms of tyrosine 3-monooxygenase (tyrosine hydroxylase; TH) occur only in primates. New TH isoforms produced by skipping of exon 3 in the adrenal medulla of patients with progressive supranuclear palsy (PSP) have recently been reported, J. Neurochem. 67 (1996) 19. Here, we looked for the presence of new TH isoforms in control brains and adrenal medulla and in brains from patients with PSP. We found a novel type of TH mRNA in the adrenal medulla from one of the control subjects. The mRNA lacked exon 4, resulting in a premature stop codon at amino acid 147. This result suggests the importance of alternative splicing in the regulation of TH activity.

Original language	English
Pages (from-to)	157-160
Number of pages	4
Journal	Neuroscience Letters
Volume	312
Issue number	3
DOIs	https://doi.org/10.1016/S0304-3940(01)02210-8
Publication status	Published - 26-10-2001

All Science Journal Classification (ASJC) codes

Neuroscience(all)

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10.1016/S0304-3940(01)02210-8

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title = "A new splicing variant for human tyrosine hydroxylase in the adrenal medulla",

abstract = "It has been reported that several mRNA isoforms of tyrosine 3-monooxygenase (tyrosine hydroxylase; TH) occur only in primates. New TH isoforms produced by skipping of exon 3 in the adrenal medulla of patients with progressive supranuclear palsy (PSP) have recently been reported, J. Neurochem. 67 (1996) 19. Here, we looked for the presence of new TH isoforms in control brains and adrenal medulla and in brains from patients with PSP. We found a novel type of TH mRNA in the adrenal medulla from one of the control subjects. The mRNA lacked exon 4, resulting in a premature stop codon at amino acid 147. This result suggests the importance of alternative splicing in the regulation of TH activity.",

author = "Tamae Ohye and Hiroshi Ichinose and Toshihiro Yoshizawa and Ichiro Kanazawa and Toshiharu Nagatsu",

note = "Funding Information: This work was supported by Health Science Grants, Research on Brain Science from the Ministry of Health and Welfare of Japan (to T.N.), and by a Grant-in-Aid for Scientific Research on Priority Areas from the Ministry of Education, Science, Sports and Culture of Japan (to T.N.).",

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T1 - A new splicing variant for human tyrosine hydroxylase in the adrenal medulla

AU - Ohye, Tamae

AU - Ichinose, Hiroshi

AU - Yoshizawa, Toshihiro

AU - Kanazawa, Ichiro

AU - Nagatsu, Toshiharu

N1 - Funding Information: This work was supported by Health Science Grants, Research on Brain Science from the Ministry of Health and Welfare of Japan (to T.N.), and by a Grant-in-Aid for Scientific Research on Priority Areas from the Ministry of Education, Science, Sports and Culture of Japan (to T.N.).

PY - 2001/10/26

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N2 - It has been reported that several mRNA isoforms of tyrosine 3-monooxygenase (tyrosine hydroxylase; TH) occur only in primates. New TH isoforms produced by skipping of exon 3 in the adrenal medulla of patients with progressive supranuclear palsy (PSP) have recently been reported, J. Neurochem. 67 (1996) 19. Here, we looked for the presence of new TH isoforms in control brains and adrenal medulla and in brains from patients with PSP. We found a novel type of TH mRNA in the adrenal medulla from one of the control subjects. The mRNA lacked exon 4, resulting in a premature stop codon at amino acid 147. This result suggests the importance of alternative splicing in the regulation of TH activity.

AB - It has been reported that several mRNA isoforms of tyrosine 3-monooxygenase (tyrosine hydroxylase; TH) occur only in primates. New TH isoforms produced by skipping of exon 3 in the adrenal medulla of patients with progressive supranuclear palsy (PSP) have recently been reported, J. Neurochem. 67 (1996) 19. Here, we looked for the presence of new TH isoforms in control brains and adrenal medulla and in brains from patients with PSP. We found a novel type of TH mRNA in the adrenal medulla from one of the control subjects. The mRNA lacked exon 4, resulting in a premature stop codon at amino acid 147. This result suggests the importance of alternative splicing in the regulation of TH activity.

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