TY - JOUR
T1 - A nonhuman primate model for human cerebral malaria
T2 - Rhesus-monkeys experimentally infected with plasmodium fragile
AU - Fujioka, Hisashi
AU - Millet, Pascal
AU - Maeno, Yoshimasa
AU - Nakazawa, Shusuke
AU - Ito, Yoshihiro
AU - Howard, Russell J.
AU - Collins, William E.
AU - Aikawa, Masamichi
PY - 1994/6
Y1 - 1994/6
N2 - We studied the brains of rhesus monkeys infected with the primate malaria parasite Plasmodium fragile. Electron microscopy showed that, in these animals, erythrocytes infected with P. fragile undergo sequestration and that parasitized red blood cells adhere to endothelial cells in the cerebral microvessels by means of knobs. Cerebral microvessels with sequestered parasitized red blood cells were shown by immunohistochemical analysis to possess the platelet glycoprotein CD36, thrombospondin, and intracellular adhesion molecule-1. The formation of rosettes also was observed in the cerebral microvessels. In a fashion similar to human cerebral malaria, P. fragile produced neurological symptoms in the animals. Thus, rhesus monkeys infected with P. fragile, like those monkeys infected with Plasmodium coatneyi, can be used as a primate model to study human cerebral malaria.
AB - We studied the brains of rhesus monkeys infected with the primate malaria parasite Plasmodium fragile. Electron microscopy showed that, in these animals, erythrocytes infected with P. fragile undergo sequestration and that parasitized red blood cells adhere to endothelial cells in the cerebral microvessels by means of knobs. Cerebral microvessels with sequestered parasitized red blood cells were shown by immunohistochemical analysis to possess the platelet glycoprotein CD36, thrombospondin, and intracellular adhesion molecule-1. The formation of rosettes also was observed in the cerebral microvessels. In a fashion similar to human cerebral malaria, P. fragile produced neurological symptoms in the animals. Thus, rhesus monkeys infected with P. fragile, like those monkeys infected with Plasmodium coatneyi, can be used as a primate model to study human cerebral malaria.
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U2 - 10.1006/expr.1994.1040
DO - 10.1006/expr.1994.1040
M3 - Article
C2 - 7515825
AN - SCOPUS:0027930549
SN - 0014-4894
VL - 78
SP - 371
EP - 376
JO - Experimental Parasitology
JF - Experimental Parasitology
IS - 4
M1 - 71040
ER -
