A nonhuman primate model for human cerebral malaria

Rhesus-monkeys experimentally infected with plasmodium fragile

Hisashi Fujioka, Pascal Millet, Yoshimasa Maeno, Shusuke Nakazawa, Yoshihiro Ito, Russell J. Howard, William E. Collins, Masamichi Aikawa

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

We studied the brains of rhesus monkeys infected with the primate malaria parasite Plasmodium fragile. Electron microscopy showed that, in these animals, erythrocytes infected with P. fragile undergo sequestration and that parasitized red blood cells adhere to endothelial cells in the cerebral microvessels by means of knobs. Cerebral microvessels with sequestered parasitized red blood cells were shown by immunohistochemical analysis to possess the platelet glycoprotein CD36, thrombospondin, and intracellular adhesion molecule-1. The formation of rosettes also was observed in the cerebral microvessels. In a fashion similar to human cerebral malaria, P. fragile produced neurological symptoms in the animals. Thus, rhesus monkeys infected with P. fragile, like those monkeys infected with Plasmodium coatneyi, can be used as a primate model to study human cerebral malaria.

Original languageEnglish
Article number71040
Pages (from-to)371-376
Number of pages6
JournalExperimental Parasitology
Volume78
Issue number4
DOIs
Publication statusPublished - 01-01-1994

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Cerebral Malaria
Plasmodium
Microvessels
Macaca mulatta
Primates
Erythrocytes
Plasmodium malariae
Thrombospondins
Platelet Membrane Glycoproteins
Rosette Formation
Haplorhini
Electron Microscopy
Parasites
Endothelial Cells
Brain

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Immunology
  • Infectious Diseases

Cite this

Fujioka, Hisashi ; Millet, Pascal ; Maeno, Yoshimasa ; Nakazawa, Shusuke ; Ito, Yoshihiro ; Howard, Russell J. ; Collins, William E. ; Aikawa, Masamichi. / A nonhuman primate model for human cerebral malaria : Rhesus-monkeys experimentally infected with plasmodium fragile. In: Experimental Parasitology. 1994 ; Vol. 78, No. 4. pp. 371-376.
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Fujioka, H, Millet, P, Maeno, Y, Nakazawa, S, Ito, Y, Howard, RJ, Collins, WE & Aikawa, M 1994, 'A nonhuman primate model for human cerebral malaria: Rhesus-monkeys experimentally infected with plasmodium fragile', Experimental Parasitology, vol. 78, no. 4, 71040, pp. 371-376. https://doi.org/10.1006/expr.1994.1040

A nonhuman primate model for human cerebral malaria : Rhesus-monkeys experimentally infected with plasmodium fragile. / Fujioka, Hisashi; Millet, Pascal; Maeno, Yoshimasa; Nakazawa, Shusuke; Ito, Yoshihiro; Howard, Russell J.; Collins, William E.; Aikawa, Masamichi.

In: Experimental Parasitology, Vol. 78, No. 4, 71040, 01.01.1994, p. 371-376.

Research output: Contribution to journalArticle

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