A nonsynonymous polymorphism in the human fatty acid amide hydrolase gene did not associate with either methamphetamine dependence or schizophrenia

Yukitaka Morita, Hiroshi Ujike, Yuji Tanaka, Naohiko Uchida, Akira Nomura, Kyohei Ohtani, Makiko Kishimoto, Akiko Morio, Takaki Imamura, Ayumu Sakai, Toshiya Inada, Mutsuo Harano, Tokutaro Komiyama, Mitsuhiko Yamada, Yoshimoto Sekine, Nakao Iwata, Masaomi Iyo, Ichiro Sora, Norio Ozaki, Shigetoshi Kuroda

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Genetic contributions to the etiology of substance abuse and dependence are topics of major interest. Acute and chronic cannabis use can produce drug-induced psychosis resembling schizophrenia and worsen positive symptoms of schizophrenia. The endocannabinoid system is one of the most important neural signaling pathways implicated in substance abuse and dependence. The fatty acid amide hydrolase (FAAH) is a primary catabolic enzyme of endocannabinoids. To clarify a possible involvement of FAAH in the etiology of methamphetamine dependence/psychosis or schizophrenia, we examined the genetic association of a nonsynonymous polymorphism of the FAAH gene (Pro129Thr) by a case-control study. We found no significant association in allele and genotype frequencies of the polymorphism with either disorder. Because the Pro129Thr polymorphism reduces enzyme instability, it is unlikely that dysfunction of FAAH and enhanced endocannabinoid system induce susceptibility to either methamphetamine dependence/psychosis or schizophrenia.

Original languageEnglish
Pages (from-to)182-187
Number of pages6
JournalNeuroscience Letters
Volume376
Issue number3
DOIs
Publication statusPublished - 16-03-2005

Fingerprint

Methamphetamine
Endocannabinoids
Substance-Related Disorders
Schizophrenia
Psychotic Disorders
Genes
Substance-Induced Psychoses
Neural Pathways
Enzymes
Cannabis
Gene Frequency
Case-Control Studies
Genotype
fatty-acid amide hydrolase

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Morita, Yukitaka ; Ujike, Hiroshi ; Tanaka, Yuji ; Uchida, Naohiko ; Nomura, Akira ; Ohtani, Kyohei ; Kishimoto, Makiko ; Morio, Akiko ; Imamura, Takaki ; Sakai, Ayumu ; Inada, Toshiya ; Harano, Mutsuo ; Komiyama, Tokutaro ; Yamada, Mitsuhiko ; Sekine, Yoshimoto ; Iwata, Nakao ; Iyo, Masaomi ; Sora, Ichiro ; Ozaki, Norio ; Kuroda, Shigetoshi. / A nonsynonymous polymorphism in the human fatty acid amide hydrolase gene did not associate with either methamphetamine dependence or schizophrenia. In: Neuroscience Letters. 2005 ; Vol. 376, No. 3. pp. 182-187.
@article{9e0d32626d3b4115b9d7b51edc8f5d27,
title = "A nonsynonymous polymorphism in the human fatty acid amide hydrolase gene did not associate with either methamphetamine dependence or schizophrenia",
abstract = "Genetic contributions to the etiology of substance abuse and dependence are topics of major interest. Acute and chronic cannabis use can produce drug-induced psychosis resembling schizophrenia and worsen positive symptoms of schizophrenia. The endocannabinoid system is one of the most important neural signaling pathways implicated in substance abuse and dependence. The fatty acid amide hydrolase (FAAH) is a primary catabolic enzyme of endocannabinoids. To clarify a possible involvement of FAAH in the etiology of methamphetamine dependence/psychosis or schizophrenia, we examined the genetic association of a nonsynonymous polymorphism of the FAAH gene (Pro129Thr) by a case-control study. We found no significant association in allele and genotype frequencies of the polymorphism with either disorder. Because the Pro129Thr polymorphism reduces enzyme instability, it is unlikely that dysfunction of FAAH and enhanced endocannabinoid system induce susceptibility to either methamphetamine dependence/psychosis or schizophrenia.",
author = "Yukitaka Morita and Hiroshi Ujike and Yuji Tanaka and Naohiko Uchida and Akira Nomura and Kyohei Ohtani and Makiko Kishimoto and Akiko Morio and Takaki Imamura and Ayumu Sakai and Toshiya Inada and Mutsuo Harano and Tokutaro Komiyama and Mitsuhiko Yamada and Yoshimoto Sekine and Nakao Iwata and Masaomi Iyo and Ichiro Sora and Norio Ozaki and Shigetoshi Kuroda",
year = "2005",
month = "3",
day = "16",
doi = "10.1016/j.neulet.2004.11.050",
language = "English",
volume = "376",
pages = "182--187",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

Morita, Y, Ujike, H, Tanaka, Y, Uchida, N, Nomura, A, Ohtani, K, Kishimoto, M, Morio, A, Imamura, T, Sakai, A, Inada, T, Harano, M, Komiyama, T, Yamada, M, Sekine, Y, Iwata, N, Iyo, M, Sora, I, Ozaki, N & Kuroda, S 2005, 'A nonsynonymous polymorphism in the human fatty acid amide hydrolase gene did not associate with either methamphetamine dependence or schizophrenia', Neuroscience Letters, vol. 376, no. 3, pp. 182-187. https://doi.org/10.1016/j.neulet.2004.11.050

A nonsynonymous polymorphism in the human fatty acid amide hydrolase gene did not associate with either methamphetamine dependence or schizophrenia. / Morita, Yukitaka; Ujike, Hiroshi; Tanaka, Yuji; Uchida, Naohiko; Nomura, Akira; Ohtani, Kyohei; Kishimoto, Makiko; Morio, Akiko; Imamura, Takaki; Sakai, Ayumu; Inada, Toshiya; Harano, Mutsuo; Komiyama, Tokutaro; Yamada, Mitsuhiko; Sekine, Yoshimoto; Iwata, Nakao; Iyo, Masaomi; Sora, Ichiro; Ozaki, Norio; Kuroda, Shigetoshi.

In: Neuroscience Letters, Vol. 376, No. 3, 16.03.2005, p. 182-187.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A nonsynonymous polymorphism in the human fatty acid amide hydrolase gene did not associate with either methamphetamine dependence or schizophrenia

AU - Morita, Yukitaka

AU - Ujike, Hiroshi

AU - Tanaka, Yuji

AU - Uchida, Naohiko

AU - Nomura, Akira

AU - Ohtani, Kyohei

AU - Kishimoto, Makiko

AU - Morio, Akiko

AU - Imamura, Takaki

AU - Sakai, Ayumu

AU - Inada, Toshiya

AU - Harano, Mutsuo

AU - Komiyama, Tokutaro

AU - Yamada, Mitsuhiko

AU - Sekine, Yoshimoto

AU - Iwata, Nakao

AU - Iyo, Masaomi

AU - Sora, Ichiro

AU - Ozaki, Norio

AU - Kuroda, Shigetoshi

PY - 2005/3/16

Y1 - 2005/3/16

N2 - Genetic contributions to the etiology of substance abuse and dependence are topics of major interest. Acute and chronic cannabis use can produce drug-induced psychosis resembling schizophrenia and worsen positive symptoms of schizophrenia. The endocannabinoid system is one of the most important neural signaling pathways implicated in substance abuse and dependence. The fatty acid amide hydrolase (FAAH) is a primary catabolic enzyme of endocannabinoids. To clarify a possible involvement of FAAH in the etiology of methamphetamine dependence/psychosis or schizophrenia, we examined the genetic association of a nonsynonymous polymorphism of the FAAH gene (Pro129Thr) by a case-control study. We found no significant association in allele and genotype frequencies of the polymorphism with either disorder. Because the Pro129Thr polymorphism reduces enzyme instability, it is unlikely that dysfunction of FAAH and enhanced endocannabinoid system induce susceptibility to either methamphetamine dependence/psychosis or schizophrenia.

AB - Genetic contributions to the etiology of substance abuse and dependence are topics of major interest. Acute and chronic cannabis use can produce drug-induced psychosis resembling schizophrenia and worsen positive symptoms of schizophrenia. The endocannabinoid system is one of the most important neural signaling pathways implicated in substance abuse and dependence. The fatty acid amide hydrolase (FAAH) is a primary catabolic enzyme of endocannabinoids. To clarify a possible involvement of FAAH in the etiology of methamphetamine dependence/psychosis or schizophrenia, we examined the genetic association of a nonsynonymous polymorphism of the FAAH gene (Pro129Thr) by a case-control study. We found no significant association in allele and genotype frequencies of the polymorphism with either disorder. Because the Pro129Thr polymorphism reduces enzyme instability, it is unlikely that dysfunction of FAAH and enhanced endocannabinoid system induce susceptibility to either methamphetamine dependence/psychosis or schizophrenia.

UR - http://www.scopus.com/inward/record.url?scp=20844461118&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20844461118&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2004.11.050

DO - 10.1016/j.neulet.2004.11.050

M3 - Article

VL - 376

SP - 182

EP - 187

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 3

ER -