A novel anticancer drug delivery system -DAC-70/CDDP

Akio Sugitachi, Koki Otsuka, Kentaro Fujisawa, Tetsuya Itabashi, Yuji Akiyama, Akira Sasaki, Kenichiro Ikeda, Yasuo Yoshida, Yoshimori Takamori, Seiji Kurozumi, Takatoshi Mori, G. Wakabayashi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

We devised a muco-adhesive anticancer drug delivery system using 70% deacetylated chitin (DAC-70) and cisplatin (CDDP) and 5-fluorouracil (5-FU). The adhesive force between the system and human colonic mucosa was measured ex vivo, and a release profile of each drug was examined in vitro. Each system demonstrated a stronger muco-adhesive force at 37 degrees C than that of 25 degrees C. The CDDP-loaded system showed a sustained release of the drug while the 5-FU-loaded system exhibited an initial bursting of the agent. We presume that the release profile of CDDP and 5-FU is closely related to both degradability of the chitin and interactions between the chitin and each drug. The DAC-70/CDDP system would be clinically promising in loco-regional cancer chemotherapy.

Original languageEnglish
Pages (from-to)2159-2161
Number of pages3
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume34
Issue number12
Publication statusPublished - 11-2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Fingerprint

Dive into the research topics of 'A novel anticancer drug delivery system -DAC-70/CDDP'. Together they form a unique fingerprint.

Cite this