A novel anticancer drug delivery system -DAC-70/CDDP

Akio Sugitachi; Koki Otsuka; Kentaro Fujisawa; Tetsuya Itabashi; Yuji Akiyama; Akira Sasaki; Kenichiro Ikeda; Yasuo Yoshida; Yoshimori Takamori; Seiji Kurozumi; Takatoshi Mori; G. Wakabayashi

A novel anticancer drug delivery system -DAC-70/CDDP

Akio Sugitachi
, Koki Otsuka
, Kentaro Fujisawa
, Tetsuya Itabashi
, Yuji Akiyama
, Akira Sasaki
, Kenichiro Ikeda
, Yasuo Yoshida
, Yoshimori Takamori
, Seiji Kurozumi
, Takatoshi Mori
, G. Wakabayashi

Research output: Contribution to journal › Article › peer-review

Abstract

We devised a muco-adhesive anticancer drug delivery system using 70% deacetylated chitin (DAC-70) and cisplatin (CDDP) and 5-fluorouracil (5-FU). The adhesive force between the system and human colonic mucosa was measured ex vivo, and a release profile of each drug was examined in vitro. Each system demonstrated a stronger muco-adhesive force at 37 degrees C than that of 25 degrees C. The CDDP-loaded system showed a sustained release of the drug while the 5-FU-loaded system exhibited an initial bursting of the agent. We presume that the release profile of CDDP and 5-FU is closely related to both degradability of the chitin and interactions between the chitin and each drug. The DAC-70/CDDP system would be clinically promising in loco-regional cancer chemotherapy.

Original language	English
Pages (from-to)	2159-2161
Number of pages	3
Journal	Gan to kagaku ryoho. Cancer & chemotherapy
Volume	34
Issue number	12
Publication status	Published - 11-2007
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

General Medicine

Cite this

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title = "A novel anticancer drug delivery system -DAC-70/CDDP",

abstract = "We devised a muco-adhesive anticancer drug delivery system using 70\% deacetylated chitin (DAC-70) and cisplatin (CDDP) and 5-fluorouracil (5-FU). The adhesive force between the system and human colonic mucosa was measured ex vivo, and a release profile of each drug was examined in vitro. Each system demonstrated a stronger muco-adhesive force at 37 degrees C than that of 25 degrees C. The CDDP-loaded system showed a sustained release of the drug while the 5-FU-loaded system exhibited an initial bursting of the agent. We presume that the release profile of CDDP and 5-FU is closely related to both degradability of the chitin and interactions between the chitin and each drug. The DAC-70/CDDP system would be clinically promising in loco-regional cancer chemotherapy.",

author = "Akio Sugitachi and Koki Otsuka and Kentaro Fujisawa and Tetsuya Itabashi and Yuji Akiyama and Akira Sasaki and Kenichiro Ikeda and Yasuo Yoshida and Yoshimori Takamori and Seiji Kurozumi and Takatoshi Mori and G. Wakabayashi",

year = "2007",

month = nov,

language = "English",

volume = "34",

pages = "2159--2161",

journal = "Gan to kagaku ryoho. Cancer \& chemotherapy",

issn = "0385-0684",

publisher = "Japanese Journal of Cancer and Chemotherapy Publishers Inc.",

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TY - JOUR

T1 - A novel anticancer drug delivery system -DAC-70/CDDP

AU - Sugitachi, Akio

AU - Otsuka, Koki

AU - Fujisawa, Kentaro

AU - Itabashi, Tetsuya

AU - Akiyama, Yuji

AU - Sasaki, Akira

AU - Ikeda, Kenichiro

AU - Yoshida, Yasuo

AU - Takamori, Yoshimori

AU - Kurozumi, Seiji

AU - Mori, Takatoshi

AU - Wakabayashi, G.

PY - 2007/11

Y1 - 2007/11

N2 - We devised a muco-adhesive anticancer drug delivery system using 70% deacetylated chitin (DAC-70) and cisplatin (CDDP) and 5-fluorouracil (5-FU). The adhesive force between the system and human colonic mucosa was measured ex vivo, and a release profile of each drug was examined in vitro. Each system demonstrated a stronger muco-adhesive force at 37 degrees C than that of 25 degrees C. The CDDP-loaded system showed a sustained release of the drug while the 5-FU-loaded system exhibited an initial bursting of the agent. We presume that the release profile of CDDP and 5-FU is closely related to both degradability of the chitin and interactions between the chitin and each drug. The DAC-70/CDDP system would be clinically promising in loco-regional cancer chemotherapy.

AB - We devised a muco-adhesive anticancer drug delivery system using 70% deacetylated chitin (DAC-70) and cisplatin (CDDP) and 5-fluorouracil (5-FU). The adhesive force between the system and human colonic mucosa was measured ex vivo, and a release profile of each drug was examined in vitro. Each system demonstrated a stronger muco-adhesive force at 37 degrees C than that of 25 degrees C. The CDDP-loaded system showed a sustained release of the drug while the 5-FU-loaded system exhibited an initial bursting of the agent. We presume that the release profile of CDDP and 5-FU is closely related to both degradability of the chitin and interactions between the chitin and each drug. The DAC-70/CDDP system would be clinically promising in loco-regional cancer chemotherapy.

UR - https://www.scopus.com/pages/publications/39049133963

UR - https://www.scopus.com/pages/publications/39049133963#tab=citedBy

M3 - Article

C2 - 18219931

AN - SCOPUS:39049133963

SN - 0385-0684

VL - 34

SP - 2159

EP - 2161

JO - Gan to kagaku ryoho. Cancer & chemotherapy

JF - Gan to kagaku ryoho. Cancer & chemotherapy

IS - 12

ER -

A novel anticancer drug delivery system -DAC-70/CDDP

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

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