A novel approach to loco-regional cancer chemotherapy with a chitosan-CDDP solution

Koki Otsuka, Yuji Akiyama, Tetsuya Itabashi, Akira Sasaki, Ken ichiro Ikeda, Yoshimori Takamori, Seiji Kurozumi, G. Wakabayashi

Research output: Contribution to journalArticlepeer-review

Abstract

The authors applied 70% deacetylated chitin (DAC 70, chitosan) as a vehicle of cis-platinum (CDDP) to achieve loco-regional cancer chemotherapy, in an attempt to hold the drug in the target region with a locally sustained release. The DAC-70 powder was dissolved in a 0.1 M HCI solution into where CDDP solution and glycerol phosphate solution were added. The resulting product, DAC-70/CDDP became a muco-adhesive solution. The adhesiveness between the solution and human colonic mucosa was measured ex vivo by our own method, and a release profile of the CDDP was examined in vitro using an atomic absorption method. The adhesive force was stronger at 37 degrees C than that of at 25 degrees C. Ten percent of the CDDP was gradually delivered for 6 hours, while the release was maintained at the same levels for the following 72 hours. The release rate increased by 10-20% when lysozyme was added in the incubation systems. However, the release profile of the drug showed no remarkable changes. The DAC-70/CDDP solution provided a favorable adhesiveness with human colonic mucosa, while in situ degradability of the solution should be improved further more.

Original languageEnglish
Pages (from-to)1866-1868
Number of pages3
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume33
Issue number12
Publication statusPublished - 11-2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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