[A novel Cisplatin delivery system for malignant ascites-bearing mice-a basic experimentation].

Tetsuya Itabashi, Akio Sugitachi, Yusuke Kimura, Miyuki Ikeda, Manami Kumagai, Teppei Matsuo, Hitoshi Fujii, Satoshi Nishizuka, Koki Otsuka, Keisuke Koeda, Akira Sasaki, G. Wakabayashi

Research output: Contribution to journalArticlepeer-review

Abstract

The authors used 70% deacetylated chitin and cisplatin (CDDP) to devise a novel anticancer drug delivery system (DDS). We examined in vitro release of the CDDP from the system. The novel system was intraperitoneally( ip) given to malignant ascites-bearing mice, and the survival time of each animal was recorded. The related oncolytic mechanism was immunologically investigated. More than 70-90% of the CDDP was gradually delivered from the system in 24 hours. Nineteen animals among 30 treated with our system survived for longer than 4 weeks, and a recurrence of ascites was nil. A 4- week survival rate of the animals with ip injected conventional CDDP was 5/14. All non-treated animals had massive ascites and died within 4 weeks. Immunologic studies suggested that cytotoxic immunoresponse was induced in the mice treated with the novel system. Our newly devised system warrants for clinical applications in the treatment of malignant ascites.

Original languageEnglish
Pages (from-to)2081-2083
Number of pages3
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume38
Issue number12
Publication statusPublished - 11-2011

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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