A novel formulation of cisplatin (CDDP)

Akio Sugitachi, Yusuke Kimura, Tetsuya Itabashi, Hironobu Noda, Kazushige Ishida, Satoshi Nishizuka, Koki Otsuka, Masahiro Kashiwaba, Hiroyuki Nitta, Keisuke Koeda, Masaru Mizuno, Akira Sasaki, Kenichiro Ikeda, Yoshimori Takamori, Go Wakabayashi

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

The study aimed to assess our newly devised CDDP delivery system designed to provide targeting potential and a sustained release of the anticancer agent. Seventy percent deacetylated chitin was applied as a drug carrier. We prepared two different types of systems with two different procedures: namely, system A with direct method and system B with indirect method. The targeting property of the system was evaluated ex vivo with measuring adhesive force between each system and human colonic mucosa. The release behavior of the CDDP from the system was examined in vitro. The anticancer activities of the released CDDP were also examined in vitro using human gastric cancer cell line, MKN-45. Each system was a viscose elastic solution. The adhesive forces of the novel systems were stronger at 37°C than that of 25°C. Each system provided a sustained release of CDDP. The released CDDP demonstrated effective growth suppression activity against the MKN-45 cancer cells. The novel systems basically showed a favorable targeting function and a sustained release of CDDP, which effectively provided a growth inhibition potential against human cancer cell line. Our newly devised CDDP delivery systems are promising as a novel approach to cancer chemotherapy.

Original languageEnglish
Pages (from-to)2294-2296
Number of pages3
JournalJapanese Journal of Cancer and Chemotherapy
Volume36
Issue number12
Publication statusPublished - 11-2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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