A novel nectin-mediated cell adhesion apparatus that is implicated in prolactin receptor signaling for mammary gland development

Midori Kitayama, Kiyohito Mizutani, Masahiro Maruoka, Kenji Mandai, Shotaro Sakakibara, Yuki Ueda, Takahide Komori, Yohei Shimono, Yoshimi Takai

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Mammary gland development is induced by the actions of various hormones to form a structure consisting of collecting ducts and milk-secreting alveoli, which comprise two types of epithelial cells known as luminal and basal cells. These cells adhere to each other by cell adhesion apparatuses whose roles in hormone-dependent mammary gland development remain largely unknown. Here we identified a novel cell adhesion apparatus at the boundary between the luminal and basal cells in addition to desmosomes. This apparatus was formed by the trans-interaction between the cell adhesion molecules nectin-4 and nectin-1, which were expressed in the luminal and basal cells, respectively. Nectin-4 of this apparatus further cis-interacted with the prolactin receptor in the luminal cells to enhance the prolactin-induced prolactin receptor signaling for alveolar development with lactogenic differentiation. Thus, a novel nectin-mediated cell adhesion apparatus regulates the prolactin receptor signaling for mammary gland development.

Original languageEnglish
Pages (from-to)5817-5831
Number of pages15
JournalJournal of Biological Chemistry
Volume291
Issue number11
DOIs
Publication statusPublished - 11-03-2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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