A palindrome-mediated recurrent translocation with 3:1 meiotic nondisjunction: The t(8;22)(q24.13;q11.21)

Molly B. Sheridan, Takema Kato, Chad Haldeman-Englert, G. Reza Jalali, Jeff M. Milunsky, Ying Zou, Ruediger Klaes, Georgio Gimelli, Stefania Gimelli, Robert M. Gemmill, Harry A. Drabkin, April M. Hacker, Julia Brown, David Tomkins, Tamim H. Shaikh, Hiroki Kurahashi, Elaine H. Zackai, Beverly S. Emanuel

Research output: Contribution to journalArticle

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Abstract

Palindrome-mediated genomic instability has been associated with chromosomal translocations, including the recurrent t(11;22)(q23;q11). We report a syndrome characterized by extremity anomalies, mild dysmorphia, and intellectual impairment caused by 3:1 meiotic segregation of a previously unrecognized recurrent palindrome-mediated rearrangement, the t(8;22)(q24.13;q11.21). There are at least ten prior reports of this translocation, and nearly identical PATRR8 and PATRR22 breakpoints were validated in several of these published cases. PCR analysis of sperm DNA from healthy males indicates that the t(8;22) arises de novo during gametogenesis in some, but not all, individuals. Furthermore, demonstration that de novo PATRR8-to-PATRR11 translocations occur in sperm suggests that palindrome-mediated translocation is a universal mechanism producing chromosomal rearrangements.

Original languageEnglish
Pages (from-to)209-218
Number of pages10
JournalAmerican Journal of Human Genetics
Volume87
Issue number2
DOIs
Publication statusPublished - 13-08-2010

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Spermatozoa
Gametogenesis
Genetic Translocation
Genomic Instability
Extremities
Polymerase Chain Reaction
DNA

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Sheridan, Molly B. ; Kato, Takema ; Haldeman-Englert, Chad ; Jalali, G. Reza ; Milunsky, Jeff M. ; Zou, Ying ; Klaes, Ruediger ; Gimelli, Georgio ; Gimelli, Stefania ; Gemmill, Robert M. ; Drabkin, Harry A. ; Hacker, April M. ; Brown, Julia ; Tomkins, David ; Shaikh, Tamim H. ; Kurahashi, Hiroki ; Zackai, Elaine H. ; Emanuel, Beverly S. / A palindrome-mediated recurrent translocation with 3:1 meiotic nondisjunction : The t(8;22)(q24.13;q11.21). In: American Journal of Human Genetics. 2010 ; Vol. 87, No. 2. pp. 209-218.
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abstract = "Palindrome-mediated genomic instability has been associated with chromosomal translocations, including the recurrent t(11;22)(q23;q11). We report a syndrome characterized by extremity anomalies, mild dysmorphia, and intellectual impairment caused by 3:1 meiotic segregation of a previously unrecognized recurrent palindrome-mediated rearrangement, the t(8;22)(q24.13;q11.21). There are at least ten prior reports of this translocation, and nearly identical PATRR8 and PATRR22 breakpoints were validated in several of these published cases. PCR analysis of sperm DNA from healthy males indicates that the t(8;22) arises de novo during gametogenesis in some, but not all, individuals. Furthermore, demonstration that de novo PATRR8-to-PATRR11 translocations occur in sperm suggests that palindrome-mediated translocation is a universal mechanism producing chromosomal rearrangements.",
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Sheridan, MB, Kato, T, Haldeman-Englert, C, Jalali, GR, Milunsky, JM, Zou, Y, Klaes, R, Gimelli, G, Gimelli, S, Gemmill, RM, Drabkin, HA, Hacker, AM, Brown, J, Tomkins, D, Shaikh, TH, Kurahashi, H, Zackai, EH & Emanuel, BS 2010, 'A palindrome-mediated recurrent translocation with 3:1 meiotic nondisjunction: The t(8;22)(q24.13;q11.21)', American Journal of Human Genetics, vol. 87, no. 2, pp. 209-218. https://doi.org/10.1016/j.ajhg.2010.07.002

A palindrome-mediated recurrent translocation with 3:1 meiotic nondisjunction : The t(8;22)(q24.13;q11.21). / Sheridan, Molly B.; Kato, Takema; Haldeman-Englert, Chad; Jalali, G. Reza; Milunsky, Jeff M.; Zou, Ying; Klaes, Ruediger; Gimelli, Georgio; Gimelli, Stefania; Gemmill, Robert M.; Drabkin, Harry A.; Hacker, April M.; Brown, Julia; Tomkins, David; Shaikh, Tamim H.; Kurahashi, Hiroki; Zackai, Elaine H.; Emanuel, Beverly S.

In: American Journal of Human Genetics, Vol. 87, No. 2, 13.08.2010, p. 209-218.

Research output: Contribution to journalArticle

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T1 - A palindrome-mediated recurrent translocation with 3:1 meiotic nondisjunction

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AU - Sheridan, Molly B.

AU - Kato, Takema

AU - Haldeman-Englert, Chad

AU - Jalali, G. Reza

AU - Milunsky, Jeff M.

AU - Zou, Ying

AU - Klaes, Ruediger

AU - Gimelli, Georgio

AU - Gimelli, Stefania

AU - Gemmill, Robert M.

AU - Drabkin, Harry A.

AU - Hacker, April M.

AU - Brown, Julia

AU - Tomkins, David

AU - Shaikh, Tamim H.

AU - Kurahashi, Hiroki

AU - Zackai, Elaine H.

AU - Emanuel, Beverly S.

PY - 2010/8/13

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N2 - Palindrome-mediated genomic instability has been associated with chromosomal translocations, including the recurrent t(11;22)(q23;q11). We report a syndrome characterized by extremity anomalies, mild dysmorphia, and intellectual impairment caused by 3:1 meiotic segregation of a previously unrecognized recurrent palindrome-mediated rearrangement, the t(8;22)(q24.13;q11.21). There are at least ten prior reports of this translocation, and nearly identical PATRR8 and PATRR22 breakpoints were validated in several of these published cases. PCR analysis of sperm DNA from healthy males indicates that the t(8;22) arises de novo during gametogenesis in some, but not all, individuals. Furthermore, demonstration that de novo PATRR8-to-PATRR11 translocations occur in sperm suggests that palindrome-mediated translocation is a universal mechanism producing chromosomal rearrangements.

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