A Patient with Giant Rippled-Pattern Sebaceoma in the Occipital Region

Masayuki Takahashi, Masaru Arima, Yohei Iwata, Kayoko Suzuki, Yoshikazu Mizoguchi, Makoto Kuroda, Kayoko Matsunaga

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4 Citations (Scopus)


A 72-year-old male visited a nearby hospital with a large tumor in his occipital region, which had existed since 20 years. Since malignant tumor was suspected, he was referred to our department. At the initial consultation, an elastic-hard, yellow-brown, sessile tumor, measuring 8 × 7 × 5 cm and with a flat surface, was observed in the occipital region. The tumor was resected and covered with artificial dermis. Histopathologically, the lesion was composed of basal-cell-like cells with nest formation in the dermis. A rippled pattern, or the single-line arrangement of tumor cells involving the stroma, was present. In addition, some tumor clusters revealed the differentiation to sebaceous glands, and these cells were positive for cytokeratin (AE1/AE3) and epithelial membrane antigen, which is consistent with the staining of sebaceous glands. On the contrary, tumor cells were negative for epithelial antigen (Ber-EP4), and Ki67 (MIB1) index was 5% or lower. Therefore, we diagnosed the tumor as rippled-pattern sebaceoma and not as basal cell carcinoma. Although this case was quite unique in its large size, immunostaining was useful for the definite diagnosis.

Original languageEnglish
Pages (from-to)107-111
Number of pages5
JournalCase Reports in Dermatology
Issue number2
Publication statusPublished - 2016

All Science Journal Classification (ASJC) codes

  • Dermatology


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