TY - JOUR
T1 - A pediatric patient with interstitial pneumonia due to enterovirus D68
AU - Matsumoto, Masaaki
AU - Awano, Hiroyuki
AU - Ogi, Miki
AU - Tomioka, Kazumi
AU - Unzaki, Ai
AU - Nishiyama, Masahiro
AU - Toyoshima, Daisaku
AU - Taniguchi-Ikeda, Mariko
AU - Ishida, Akihito
AU - Nagase, Hiroaki
AU - Morioka, Ichiro
AU - Iijima, Kazumoto
N1 - Publisher Copyright:
© 2016 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Enterovirus D68 (EV-D68) infection is associated with upper and lower respiratory tract symptoms such as fever, cough, and wheezing. Pediatric patients with EV-D68 infection easily develop more severe respiratory complications compared to patients infected with other species of enterovirus, and consequently, have a higher rate of hospitalization and admission to intensive care units. Therefore, the clinical picture of respiratory complications associated with EV-D68 infection needs to be elucidated. Here, we report a 4-year-old girl of EV-D68 infection that required artificial respiration management within 24 h from the onset of cold symptoms. The patient was diagnosed with interstitial pneumonia on the basis of chest imaging findings with patchy, funicular and frosted glassy shadows, increased blood markers of surfactant protein-A, surfactant protein-D and sialylated carbohydrate antigen KL-6, and increased neutrophils and lymphocytes in the bronchoalveolar lavage. Steroids showed a remarkable effect in her treatment. Further investigations are needed to confirm the efficacy of steroids for interstitial pneumonia due to EV-D68 infection. As rapid deterioration of respiratory status is observed in EV-D68 infection, the possibility of interstitial pneumonia may be considered.
AB - Enterovirus D68 (EV-D68) infection is associated with upper and lower respiratory tract symptoms such as fever, cough, and wheezing. Pediatric patients with EV-D68 infection easily develop more severe respiratory complications compared to patients infected with other species of enterovirus, and consequently, have a higher rate of hospitalization and admission to intensive care units. Therefore, the clinical picture of respiratory complications associated with EV-D68 infection needs to be elucidated. Here, we report a 4-year-old girl of EV-D68 infection that required artificial respiration management within 24 h from the onset of cold symptoms. The patient was diagnosed with interstitial pneumonia on the basis of chest imaging findings with patchy, funicular and frosted glassy shadows, increased blood markers of surfactant protein-A, surfactant protein-D and sialylated carbohydrate antigen KL-6, and increased neutrophils and lymphocytes in the bronchoalveolar lavage. Steroids showed a remarkable effect in her treatment. Further investigations are needed to confirm the efficacy of steroids for interstitial pneumonia due to EV-D68 infection. As rapid deterioration of respiratory status is observed in EV-D68 infection, the possibility of interstitial pneumonia may be considered.
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U2 - 10.1016/j.jiac.2016.03.009
DO - 10.1016/j.jiac.2016.03.009
M3 - Article
C2 - 27118532
AN - SCOPUS:84963964181
SN - 1341-321X
VL - 22
SP - 712
EP - 715
JO - Journal of Infection and Chemotherapy
JF - Journal of Infection and Chemotherapy
IS - 10
ER -