TY - JOUR
T1 - A pediatric patient with interstitial pneumonia due to enterovirus D68
AU - Matsumoto, Masaaki
AU - Awano, Hiroyuki
AU - Ogi, Miki
AU - Tomioka, Kazumi
AU - Unzaki, Ai
AU - Nishiyama, Masahiro
AU - Toyoshima, Daisaku
AU - Taniguchi-Ikeda, Mariko
AU - Ishida, Akihito
AU - Nagase, Hiroaki
AU - Morioka, Ichiro
AU - Iijima, Kazumoto
N1 - Funding Information:
This work was supported by Grants-in-Aid for Scientific Research (C) (grant number 26461632 ).
Funding Information:
All authors have no financial relationships relevant to this article to disclose. Outside the submitted work, Ichiro Morioka has received grants from Japan Blood Product Organization , Daiichi Sankyo Co., Ltd , MSD and AbbVie LLC ; lecture fees from MSD , Pfizer Japan, Inc. , Novo Nordisk Pharma Ltd. , Eli Lilly Japan K.K. , Shionogi Co., Ltd. , AbbVie LLC , and Atom Medical Corp. ; and a consulting fee from Sanofi K.K. and Japan Blood Product Organization . Kazumoto Iijima has received grants from Pfizer Japan, Inc. , Daiichi Sankyo Co., Ltd , Japan Blood Product Organization , Miyarisan Pharmaceutical Co., Ltd. , AbbVie LLC , CSL Behring , JCR Pharmaceuticals Co., Ltd . and Teijin Pharma Ltd. ; lecture fees from MSD , ALEXION Pharmaceuticals , AstraZeneca K.K. , Meiji Seika Pharma Co., Ltd. , Novartis Pharma K.K. , Zenyaku Kogyo Co., Ltd. , Chugai Pharmaceutical Co., Ltd. , Astellas Pharma Inc. , Daiichi Sankyo, Co., Ltd. , Springer Japan , Asahi Kasei Pharma Corp , Boehringer Ingelheim and Medical Review Co., Ltd. ; manuscript fees from Chugai Pharmaceutical Co., Ltd. ; and consulting fees from Chugai Pharmaceutical Co., Ltd. , Astellas Pharma Inc. and Takeda Pharmaceutical Company Ltd.
Publisher Copyright:
© 2016 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Enterovirus D68 (EV-D68) infection is associated with upper and lower respiratory tract symptoms such as fever, cough, and wheezing. Pediatric patients with EV-D68 infection easily develop more severe respiratory complications compared to patients infected with other species of enterovirus, and consequently, have a higher rate of hospitalization and admission to intensive care units. Therefore, the clinical picture of respiratory complications associated with EV-D68 infection needs to be elucidated. Here, we report a 4-year-old girl of EV-D68 infection that required artificial respiration management within 24 h from the onset of cold symptoms. The patient was diagnosed with interstitial pneumonia on the basis of chest imaging findings with patchy, funicular and frosted glassy shadows, increased blood markers of surfactant protein-A, surfactant protein-D and sialylated carbohydrate antigen KL-6, and increased neutrophils and lymphocytes in the bronchoalveolar lavage. Steroids showed a remarkable effect in her treatment. Further investigations are needed to confirm the efficacy of steroids for interstitial pneumonia due to EV-D68 infection. As rapid deterioration of respiratory status is observed in EV-D68 infection, the possibility of interstitial pneumonia may be considered.
AB - Enterovirus D68 (EV-D68) infection is associated with upper and lower respiratory tract symptoms such as fever, cough, and wheezing. Pediatric patients with EV-D68 infection easily develop more severe respiratory complications compared to patients infected with other species of enterovirus, and consequently, have a higher rate of hospitalization and admission to intensive care units. Therefore, the clinical picture of respiratory complications associated with EV-D68 infection needs to be elucidated. Here, we report a 4-year-old girl of EV-D68 infection that required artificial respiration management within 24 h from the onset of cold symptoms. The patient was diagnosed with interstitial pneumonia on the basis of chest imaging findings with patchy, funicular and frosted glassy shadows, increased blood markers of surfactant protein-A, surfactant protein-D and sialylated carbohydrate antigen KL-6, and increased neutrophils and lymphocytes in the bronchoalveolar lavage. Steroids showed a remarkable effect in her treatment. Further investigations are needed to confirm the efficacy of steroids for interstitial pneumonia due to EV-D68 infection. As rapid deterioration of respiratory status is observed in EV-D68 infection, the possibility of interstitial pneumonia may be considered.
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U2 - 10.1016/j.jiac.2016.03.009
DO - 10.1016/j.jiac.2016.03.009
M3 - Article
C2 - 27118532
AN - SCOPUS:84963964181
VL - 22
SP - 712
EP - 715
JO - Journal of Infection and Chemotherapy
JF - Journal of Infection and Chemotherapy
SN - 1341-321X
IS - 10
ER -