TY - JOUR
T1 - A phase 3 study of induction treatment with concurrent chemoradiotherapy versus chemotherapy before surgery in patients with pathologically confirmed N2 stage IIIA nonsmall cell lung cancer (WJTOG9903)
AU - Katakami, Nobuyuki
AU - Tada, Hirohito
AU - Mitsudomi, Tetsuya
AU - Kudoh, Shinzoh
AU - Senba, Hiroshi
AU - Matsui, Kaoru
AU - Saka, Hideo
AU - Kurata, Takayasu
AU - Nishimura, Yasumasa
AU - Fukuoka, Masahiro
PY - 2012/12/15
Y1 - 2012/12/15
N2 - BACKGROUND: This study sought to ascertain whether induction-concurrent radiotherapy added to chemotherapy could improve the survival of patients undergoing surgery for stage IIIA N2 nonsmall cell lung cancer (NSCLC). METHODS: Patients with pathologically proven N2 disease were randomized to receive either induction chemotherapy (docetaxel 60 mg/m2 and carboplatin AUC [area under the receiver operating characteristic curve] = 5 for 2 cycles) plus concurrent radiation therapy (40 Gy) followed by surgery (CRS arm) or induction chemotherapy followed by surgery (CS arm). They subsequently underwent pulmonary resection when possible. RESULTS: Sixty patients were randomly assigned between December 2000 and August 2005. The study was prematurely terminated in January 2006 because of slow accrual. The most common toxicity was grade 3 or 4 leukopenia in 92.9% of patients in the CRS arm and 46.4% in the CS arm. Induction therapy was generally well tolerated, and there were no treatment-related deaths in either arm. Downstaging in the CS arm and CRS arm was 21% and 40%, respectively. The progression-free survival (PFS) and overall survival (OS) in the CS arm were 9.7 months and 29.9 months (PFS, hazard ratio [HR] = 0.68, P =.187), and those in the CRS arm were 12.4 months and 39.6 months (OS, HR = 0.77, P =.397), respectively. The PFS with and without downstaging was 55.0 and 9.4 months, respectively (HR = 3.39, P =.001). The OS with and without downstaging was 63.3 and 29.5 months, respectively (HR = 2.62, P =.021). CONCLUSIONS: The addition of radiotherapy to induction chemotherapy conferred better local control without significant adverse events. Tumor downstaging is important for prolonging the OS in patients with stage IIIA (N2) NSCLC.
AB - BACKGROUND: This study sought to ascertain whether induction-concurrent radiotherapy added to chemotherapy could improve the survival of patients undergoing surgery for stage IIIA N2 nonsmall cell lung cancer (NSCLC). METHODS: Patients with pathologically proven N2 disease were randomized to receive either induction chemotherapy (docetaxel 60 mg/m2 and carboplatin AUC [area under the receiver operating characteristic curve] = 5 for 2 cycles) plus concurrent radiation therapy (40 Gy) followed by surgery (CRS arm) or induction chemotherapy followed by surgery (CS arm). They subsequently underwent pulmonary resection when possible. RESULTS: Sixty patients were randomly assigned between December 2000 and August 2005. The study was prematurely terminated in January 2006 because of slow accrual. The most common toxicity was grade 3 or 4 leukopenia in 92.9% of patients in the CRS arm and 46.4% in the CS arm. Induction therapy was generally well tolerated, and there were no treatment-related deaths in either arm. Downstaging in the CS arm and CRS arm was 21% and 40%, respectively. The progression-free survival (PFS) and overall survival (OS) in the CS arm were 9.7 months and 29.9 months (PFS, hazard ratio [HR] = 0.68, P =.187), and those in the CRS arm were 12.4 months and 39.6 months (OS, HR = 0.77, P =.397), respectively. The PFS with and without downstaging was 55.0 and 9.4 months, respectively (HR = 3.39, P =.001). The OS with and without downstaging was 63.3 and 29.5 months, respectively (HR = 2.62, P =.021). CONCLUSIONS: The addition of radiotherapy to induction chemotherapy conferred better local control without significant adverse events. Tumor downstaging is important for prolonging the OS in patients with stage IIIA (N2) NSCLC.
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U2 - 10.1002/cncr.26689
DO - 10.1002/cncr.26689
M3 - Article
C2 - 22674529
AN - SCOPUS:84870707346
SN - 0008-543X
VL - 118
SP - 6126
EP - 6135
JO - Cancer
JF - Cancer
IS - 24
ER -