Abstract
A polymorphism within the 3′-UTR 8473T→C of the cyclooxygenase-2 (COX-2) gene, which plays a role in gastrointestinal cancer development, has been associated with susceptibility to malignant disease. Here, we report on the interaction between the COX-2 3′-UTR T→C polymorphism and gastric cancer development. DNA from 121 Japanese patients with gastric cancer and 126 age-matched control patients was examined for the COX-2 polymorphism by PCR-RFLP. Odds ratios and the 95% confidence interval (CI) were calculated. Homozygous carriage of the COX-2 8473C allele tended to be associated with an increased risk of gastric cancer compared to the T allele homozygotes of the subjects (OR=3.70; 95% CI, 0.96-14.25). The CC allele was associated with a significant increased risk of diffuse-type gastric cancer (OR=5.29; 95% CI, 1.18-23.70). These findings suggest that the COX-2 3′-UTR 8473T→C polymorphism could be used as a marker for genetic susceptibility to gastric cancer in Japanese populations.
Original language | English |
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Pages (from-to) | 561-564 |
Number of pages | 4 |
Journal | Molecular Medicine Reports |
Volume | 1 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2008 |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Genetics
- Oncology
- Cancer Research