A polymorphism near MC4R gene (rs17782313) is associated with serum triglyceride levels in the general Japanese population: The J-MICC Study

Sakurako Katsuura-Kamano, Hirokazu Uemura, Kokichi Arisawa, Miwa Yamaguchi, Nobuyuki Hamajima, Kenji Wakai, Rieko Okada, Sadao Suzuki, Naoto Taguchi, Yoshikuni Kita, Keizo Ohnaka, Tara Sefanya Kairupan, Daisuke Matsui, Isao Oze, Haruo Mikami, Michiaki Kubo, Hideo Tanaka

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Abstract

Previously reported associations of a common polymorphism near melanocortin-4 receptor (MC4R) gene (rs17782313) with BMI/obesity were inconsistent, especially in East Asia, and the associations of the polymorphism with serum lipid levels have not been fully elucidated. This study evaluated the association between rs17782313 and obesity-related traits and serum lipid levels in the general Japanese population. A total of 2,035 subjects (aged 35-69 years, 1,024 males and 1,011 females) enrolled in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. We examined the associations between near MC4R polymorphism (rs17782313) and obesity-related traits [height, weight, body mass index (BMI), weight change from 20 years old], serum lipid levels (triglycerides, total and HDL-cholesterol), and intake of nutrients (total energy and macronutrients). Polymorphism of rs17782313 (minor C allele) was positively associated with serum triglyceride levels (P for trend = 0.020) adjusted for age and sex. Analysis using a general linear model revealed that the number of minor C alleles was positively associated with serum triglyceride levels after adjustment for age, sex, and potential confounders (P for trend = 0.004). Statistical significance did not change after further adjustment for total energy intake and BMI. There was no significant association between rs17782313 and obesity-related traits including BMI. Interactions between rs17782313 and sex, BMI, or total energy intake for triglyceride levels were not significant. To our knowledge, this study demonstrated for the first time that rs17782313 was associated with serum triglyceride levels in Asian population. Further studies are needed to confirm this result.

Original languageEnglish
Pages (from-to)81-89
Number of pages9
JournalEndocrine
Volume47
Issue number1
DOIs
Publication statusPublished - 01-01-2014

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Receptor, Melanocortin, Type 4
Japan
Triglycerides
Cohort Studies
Body Mass Index
Obesity
Serum
Population
Genes
Energy Intake
Lipids
Alleles
Weights and Measures
Far East
HDL Cholesterol
Linear Models
Food

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Katsuura-Kamano, S., Uemura, H., Arisawa, K., Yamaguchi, M., Hamajima, N., Wakai, K., ... Tanaka, H. (2014). A polymorphism near MC4R gene (rs17782313) is associated with serum triglyceride levels in the general Japanese population: The J-MICC Study. Endocrine, 47(1), 81-89. https://doi.org/10.1007/s12020-014-0306-y
Katsuura-Kamano, Sakurako ; Uemura, Hirokazu ; Arisawa, Kokichi ; Yamaguchi, Miwa ; Hamajima, Nobuyuki ; Wakai, Kenji ; Okada, Rieko ; Suzuki, Sadao ; Taguchi, Naoto ; Kita, Yoshikuni ; Ohnaka, Keizo ; Kairupan, Tara Sefanya ; Matsui, Daisuke ; Oze, Isao ; Mikami, Haruo ; Kubo, Michiaki ; Tanaka, Hideo. / A polymorphism near MC4R gene (rs17782313) is associated with serum triglyceride levels in the general Japanese population : The J-MICC Study. In: Endocrine. 2014 ; Vol. 47, No. 1. pp. 81-89.
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abstract = "Previously reported associations of a common polymorphism near melanocortin-4 receptor (MC4R) gene (rs17782313) with BMI/obesity were inconsistent, especially in East Asia, and the associations of the polymorphism with serum lipid levels have not been fully elucidated. This study evaluated the association between rs17782313 and obesity-related traits and serum lipid levels in the general Japanese population. A total of 2,035 subjects (aged 35-69 years, 1,024 males and 1,011 females) enrolled in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. We examined the associations between near MC4R polymorphism (rs17782313) and obesity-related traits [height, weight, body mass index (BMI), weight change from 20 years old], serum lipid levels (triglycerides, total and HDL-cholesterol), and intake of nutrients (total energy and macronutrients). Polymorphism of rs17782313 (minor C allele) was positively associated with serum triglyceride levels (P for trend = 0.020) adjusted for age and sex. Analysis using a general linear model revealed that the number of minor C alleles was positively associated with serum triglyceride levels after adjustment for age, sex, and potential confounders (P for trend = 0.004). Statistical significance did not change after further adjustment for total energy intake and BMI. There was no significant association between rs17782313 and obesity-related traits including BMI. Interactions between rs17782313 and sex, BMI, or total energy intake for triglyceride levels were not significant. To our knowledge, this study demonstrated for the first time that rs17782313 was associated with serum triglyceride levels in Asian population. Further studies are needed to confirm this result.",
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Katsuura-Kamano, S, Uemura, H, Arisawa, K, Yamaguchi, M, Hamajima, N, Wakai, K, Okada, R, Suzuki, S, Taguchi, N, Kita, Y, Ohnaka, K, Kairupan, TS, Matsui, D, Oze, I, Mikami, H, Kubo, M & Tanaka, H 2014, 'A polymorphism near MC4R gene (rs17782313) is associated with serum triglyceride levels in the general Japanese population: The J-MICC Study', Endocrine, vol. 47, no. 1, pp. 81-89. https://doi.org/10.1007/s12020-014-0306-y

A polymorphism near MC4R gene (rs17782313) is associated with serum triglyceride levels in the general Japanese population : The J-MICC Study. / Katsuura-Kamano, Sakurako; Uemura, Hirokazu; Arisawa, Kokichi; Yamaguchi, Miwa; Hamajima, Nobuyuki; Wakai, Kenji; Okada, Rieko; Suzuki, Sadao; Taguchi, Naoto; Kita, Yoshikuni; Ohnaka, Keizo; Kairupan, Tara Sefanya; Matsui, Daisuke; Oze, Isao; Mikami, Haruo; Kubo, Michiaki; Tanaka, Hideo.

In: Endocrine, Vol. 47, No. 1, 01.01.2014, p. 81-89.

Research output: Contribution to journalArticle

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T1 - A polymorphism near MC4R gene (rs17782313) is associated with serum triglyceride levels in the general Japanese population

T2 - The J-MICC Study

AU - Katsuura-Kamano, Sakurako

AU - Uemura, Hirokazu

AU - Arisawa, Kokichi

AU - Yamaguchi, Miwa

AU - Hamajima, Nobuyuki

AU - Wakai, Kenji

AU - Okada, Rieko

AU - Suzuki, Sadao

AU - Taguchi, Naoto

AU - Kita, Yoshikuni

AU - Ohnaka, Keizo

AU - Kairupan, Tara Sefanya

AU - Matsui, Daisuke

AU - Oze, Isao

AU - Mikami, Haruo

AU - Kubo, Michiaki

AU - Tanaka, Hideo

PY - 2014/1/1

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N2 - Previously reported associations of a common polymorphism near melanocortin-4 receptor (MC4R) gene (rs17782313) with BMI/obesity were inconsistent, especially in East Asia, and the associations of the polymorphism with serum lipid levels have not been fully elucidated. This study evaluated the association between rs17782313 and obesity-related traits and serum lipid levels in the general Japanese population. A total of 2,035 subjects (aged 35-69 years, 1,024 males and 1,011 females) enrolled in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. We examined the associations between near MC4R polymorphism (rs17782313) and obesity-related traits [height, weight, body mass index (BMI), weight change from 20 years old], serum lipid levels (triglycerides, total and HDL-cholesterol), and intake of nutrients (total energy and macronutrients). Polymorphism of rs17782313 (minor C allele) was positively associated with serum triglyceride levels (P for trend = 0.020) adjusted for age and sex. Analysis using a general linear model revealed that the number of minor C alleles was positively associated with serum triglyceride levels after adjustment for age, sex, and potential confounders (P for trend = 0.004). Statistical significance did not change after further adjustment for total energy intake and BMI. There was no significant association between rs17782313 and obesity-related traits including BMI. Interactions between rs17782313 and sex, BMI, or total energy intake for triglyceride levels were not significant. To our knowledge, this study demonstrated for the first time that rs17782313 was associated with serum triglyceride levels in Asian population. Further studies are needed to confirm this result.

AB - Previously reported associations of a common polymorphism near melanocortin-4 receptor (MC4R) gene (rs17782313) with BMI/obesity were inconsistent, especially in East Asia, and the associations of the polymorphism with serum lipid levels have not been fully elucidated. This study evaluated the association between rs17782313 and obesity-related traits and serum lipid levels in the general Japanese population. A total of 2,035 subjects (aged 35-69 years, 1,024 males and 1,011 females) enrolled in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. We examined the associations between near MC4R polymorphism (rs17782313) and obesity-related traits [height, weight, body mass index (BMI), weight change from 20 years old], serum lipid levels (triglycerides, total and HDL-cholesterol), and intake of nutrients (total energy and macronutrients). Polymorphism of rs17782313 (minor C allele) was positively associated with serum triglyceride levels (P for trend = 0.020) adjusted for age and sex. Analysis using a general linear model revealed that the number of minor C alleles was positively associated with serum triglyceride levels after adjustment for age, sex, and potential confounders (P for trend = 0.004). Statistical significance did not change after further adjustment for total energy intake and BMI. There was no significant association between rs17782313 and obesity-related traits including BMI. Interactions between rs17782313 and sex, BMI, or total energy intake for triglyceride levels were not significant. To our knowledge, this study demonstrated for the first time that rs17782313 was associated with serum triglyceride levels in Asian population. Further studies are needed to confirm this result.

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