A Population-based follow-up study on mortality from cancer or cardiovascular disease and serum carotenoids, retinol and tocopherols in Japanese Inhabitants

Yoshinori Ito, Koji Suzuki, Junichi Ishii, Hitoshi Hishida, Akiko Tamakoshi, Nobuyuki Hamajima, Kunio Aoki

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Objective: Observational epidemiologic studies have shown that a high intake of dietary and high serum levels of carotenoids are associated with a reduced risk of mortality from cancer and cardiovascular disease. To investigate whether high serum levels of carotenoids can reduce mortality rates, a population-based follow-up study was conducted among Japanese inhabitants. Materials and Methods: Three thousand two hundred and fifty-four subjects (1,260 males and 1,994 females) aged from 39 to 85 years who had attended health check-up programs from 1989 to 1995 were recruited from the Japanese population. Serum levels of carotenoids, retinol and tocopherols were separately determined by high-performance liquid chromatography. Hazard ratios for serum values of carotenoids, retinol and tocopherols were estimated by Cox's proportional hazard model after adjusting for sex, age, and other confounding factors. Results: During the 11.7-year follow-up period, 140 deaths (86 males and 54 females) from cancer of all sites were identified among the cohort subjects, including 41 from lung, 17 from stomach, 16 from colorectal and 12 from liver cancer, as well as 89 deaths from cardiovascular disease, including 45 from heart disease and 37 from stroke. High serum values of carotenoids including xanthophylls were apparently associated with low hazard ratios for mortality rates of cancer of all sites or of cardiovascular disease. High serum values of β-carotene, total carotene, provitamin A and total carotenoid for colorectal cancer or stroke also appeared to be related to low hazard ratios. Those of retinol and tocopherols were not associated with any reduction in risk of mortality from cancer or cardiovascular disease. Conclusions: Our follow-up study demonstrated that a typical Japanese diet related to elevating serum levels of carotenoids with provitamin A activity may significantly reduce risk of mortality from cancer of certain sites or cardiovascular disease, especially colorectal cancer or stroke, while high serum levels of some xanthophylls, retinol and tocopherols do not.

Original languageEnglish
Pages (from-to)533-546
Number of pages14
JournalAsian Pacific Journal of Cancer Prevention
Volume7
Issue number4
Publication statusPublished - 01-01-2006

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Tocopherols
Carotenoids
Vitamin A
Cardiovascular Diseases
Mortality
Serum
Population
Neoplasms
Xanthophylls
Stroke
Colorectal Neoplasms
Risk Reduction Behavior
Liver Neoplasms
Proportional Hazards Models
Observational Studies
Epidemiologic Studies
Heart Diseases
Stomach
High Pressure Liquid Chromatography
Diet

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

Cite this

@article{8ed6add1ca5d448e929027390c28c08e,
title = "A Population-based follow-up study on mortality from cancer or cardiovascular disease and serum carotenoids, retinol and tocopherols in Japanese Inhabitants",
abstract = "Objective: Observational epidemiologic studies have shown that a high intake of dietary and high serum levels of carotenoids are associated with a reduced risk of mortality from cancer and cardiovascular disease. To investigate whether high serum levels of carotenoids can reduce mortality rates, a population-based follow-up study was conducted among Japanese inhabitants. Materials and Methods: Three thousand two hundred and fifty-four subjects (1,260 males and 1,994 females) aged from 39 to 85 years who had attended health check-up programs from 1989 to 1995 were recruited from the Japanese population. Serum levels of carotenoids, retinol and tocopherols were separately determined by high-performance liquid chromatography. Hazard ratios for serum values of carotenoids, retinol and tocopherols were estimated by Cox's proportional hazard model after adjusting for sex, age, and other confounding factors. Results: During the 11.7-year follow-up period, 140 deaths (86 males and 54 females) from cancer of all sites were identified among the cohort subjects, including 41 from lung, 17 from stomach, 16 from colorectal and 12 from liver cancer, as well as 89 deaths from cardiovascular disease, including 45 from heart disease and 37 from stroke. High serum values of carotenoids including xanthophylls were apparently associated with low hazard ratios for mortality rates of cancer of all sites or of cardiovascular disease. High serum values of β-carotene, total carotene, provitamin A and total carotenoid for colorectal cancer or stroke also appeared to be related to low hazard ratios. Those of retinol and tocopherols were not associated with any reduction in risk of mortality from cancer or cardiovascular disease. Conclusions: Our follow-up study demonstrated that a typical Japanese diet related to elevating serum levels of carotenoids with provitamin A activity may significantly reduce risk of mortality from cancer of certain sites or cardiovascular disease, especially colorectal cancer or stroke, while high serum levels of some xanthophylls, retinol and tocopherols do not.",
author = "Yoshinori Ito and Koji Suzuki and Junichi Ishii and Hitoshi Hishida and Akiko Tamakoshi and Nobuyuki Hamajima and Kunio Aoki",
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A Population-based follow-up study on mortality from cancer or cardiovascular disease and serum carotenoids, retinol and tocopherols in Japanese Inhabitants. / Ito, Yoshinori; Suzuki, Koji; Ishii, Junichi; Hishida, Hitoshi; Tamakoshi, Akiko; Hamajima, Nobuyuki; Aoki, Kunio.

In: Asian Pacific Journal of Cancer Prevention, Vol. 7, No. 4, 01.01.2006, p. 533-546.

Research output: Contribution to journalArticle

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T1 - A Population-based follow-up study on mortality from cancer or cardiovascular disease and serum carotenoids, retinol and tocopherols in Japanese Inhabitants

AU - Ito, Yoshinori

AU - Suzuki, Koji

AU - Ishii, Junichi

AU - Hishida, Hitoshi

AU - Tamakoshi, Akiko

AU - Hamajima, Nobuyuki

AU - Aoki, Kunio

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Y1 - 2006/1/1

N2 - Objective: Observational epidemiologic studies have shown that a high intake of dietary and high serum levels of carotenoids are associated with a reduced risk of mortality from cancer and cardiovascular disease. To investigate whether high serum levels of carotenoids can reduce mortality rates, a population-based follow-up study was conducted among Japanese inhabitants. Materials and Methods: Three thousand two hundred and fifty-four subjects (1,260 males and 1,994 females) aged from 39 to 85 years who had attended health check-up programs from 1989 to 1995 were recruited from the Japanese population. Serum levels of carotenoids, retinol and tocopherols were separately determined by high-performance liquid chromatography. Hazard ratios for serum values of carotenoids, retinol and tocopherols were estimated by Cox's proportional hazard model after adjusting for sex, age, and other confounding factors. Results: During the 11.7-year follow-up period, 140 deaths (86 males and 54 females) from cancer of all sites were identified among the cohort subjects, including 41 from lung, 17 from stomach, 16 from colorectal and 12 from liver cancer, as well as 89 deaths from cardiovascular disease, including 45 from heart disease and 37 from stroke. High serum values of carotenoids including xanthophylls were apparently associated with low hazard ratios for mortality rates of cancer of all sites or of cardiovascular disease. High serum values of β-carotene, total carotene, provitamin A and total carotenoid for colorectal cancer or stroke also appeared to be related to low hazard ratios. Those of retinol and tocopherols were not associated with any reduction in risk of mortality from cancer or cardiovascular disease. Conclusions: Our follow-up study demonstrated that a typical Japanese diet related to elevating serum levels of carotenoids with provitamin A activity may significantly reduce risk of mortality from cancer of certain sites or cardiovascular disease, especially colorectal cancer or stroke, while high serum levels of some xanthophylls, retinol and tocopherols do not.

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