TY - JOUR
T1 - A possible role of protein kinase C in signal-induced lysosomal enzyme release
AU - Kajikawa, Norio
AU - Kaibuchi, Kozo
AU - Matsubara, Tsukasa
AU - Kikkawa, Ushio
AU - Takai, Yoshimi
AU - Nishizuka, Yasutomi
AU - Itoh, Kiyoshi
AU - Tomioka, Chikanori
PY - 1983/10/31
Y1 - 1983/10/31
N2 - In platelets, activation of protein kinase C and mobilization of Ca2+ were selectively induced by the addition of 1-oleoyl-2-acetyl-glycerol and a low concentration of A23187, respectively (Kaibuchi, K., Takai, Y., Sawamura, M., Hoshijima, M., Fujikura, T. and Nishizuka, Y. (1983) J. Biol. Chem. 258, 6701-6704). Using this procedure evidence was obtained suggesting that the protein phosphorylation and Ca2+ mobilization were both essential and synergistically effective to cause release of lysosomal acid hydrolases such as N-acetylglucosaminidase. A similar observation was made for the lysosomal enzyme release from rat neutrophils.
AB - In platelets, activation of protein kinase C and mobilization of Ca2+ were selectively induced by the addition of 1-oleoyl-2-acetyl-glycerol and a low concentration of A23187, respectively (Kaibuchi, K., Takai, Y., Sawamura, M., Hoshijima, M., Fujikura, T. and Nishizuka, Y. (1983) J. Biol. Chem. 258, 6701-6704). Using this procedure evidence was obtained suggesting that the protein phosphorylation and Ca2+ mobilization were both essential and synergistically effective to cause release of lysosomal acid hydrolases such as N-acetylglucosaminidase. A similar observation was made for the lysosomal enzyme release from rat neutrophils.
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U2 - 10.1016/0006-291X(83)90587-9
DO - 10.1016/0006-291X(83)90587-9
M3 - Article
C2 - 6228230
AN - SCOPUS:0021081910
SN - 0006-291X
VL - 116
SP - 743
EP - 750
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -