A possible role of protein kinase C in signal-induced lysosomal enzyme release

Norio Kajikawa, Kozo Kaibuchi, Tsukasa Matsubara, Ushio Kikkawa, Yoshimi Takai, Yasutomi Nishizuka, Kiyoshi Itoh, Chikanori Tomioka

Research output: Contribution to journalArticlepeer-review

77 Citations (Scopus)

Abstract

In platelets, activation of protein kinase C and mobilization of Ca2+ were selectively induced by the addition of 1-oleoyl-2-acetyl-glycerol and a low concentration of A23187, respectively (Kaibuchi, K., Takai, Y., Sawamura, M., Hoshijima, M., Fujikura, T. and Nishizuka, Y. (1983) J. Biol. Chem. 258, 6701-6704). Using this procedure evidence was obtained suggesting that the protein phosphorylation and Ca2+ mobilization were both essential and synergistically effective to cause release of lysosomal acid hydrolases such as N-acetylglucosaminidase. A similar observation was made for the lysosomal enzyme release from rat neutrophils.

Original languageEnglish
Pages (from-to)743-750
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume116
Issue number2
DOIs
Publication statusPublished - 31-10-1983
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint

Dive into the research topics of 'A possible role of protein kinase C in signal-induced lysosomal enzyme release'. Together they form a unique fingerprint.

Cite this