A prognostic index for colorectal cancer based on preoperative absolute lymphocyte, monocyte, and neutrophil counts

Akimitsu Tanio, Hiroaki Saito, Chihiro Uejima, Seigo Takaya, Manabu Yamamoto, Naruo Tokuyasu, Teruhisa Sakamoto, Soichiro Honjo, Keigo Ashida, Yoshiyuki Fujiwara

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Purpose: Associations between the preoperative absolute neutrophil count (NC), lymphocyte count (LC), and monocyte count (MC) in the peripheral blood and the prognosis of colorectal cancer (CRC) patients have not been widely studied. Methods: We enrolled 361 patients who underwent surgery for CRC between January 2007 and December 2013 to analyze correlations among the LC, MC, and NC and prognosis. Results: Based on cut-off values determined by a receiver operating characteristic analysis, patients were subgrouped as Lymph High or Lymph Low (cut-off: LC = 1460 cells/µL); as Mono High or Mono Low (cut-off: MC = 421 cells/µL); and as Neut High or Neut Low (cut-off: NC = 3247 cells/µL). Patients were then given lymphocyte–monocyte–neutrophil (LMN) scores by adding the points of their different subgroups (1 point each for Lymph Low , Mono High and Neut High ; 0 points for Lymph High , Mono Low and Neut Low ). The 5-year overall survival rates significantly differed by the LMN score (0: 89.7%, 1: 80.6%, 2: 68.8%, and 3: 57.4%; P < 0.0001). In the multivariate analysis, the LMN score was found to be an independent prognostic indicator. Conclusions: The combination of the preoperative absolute number of lymphocytes, monocytes, and neutrophils is a useful prognostic indicator in CRC patients.

Original languageEnglish
Pages (from-to)245-253
Number of pages9
JournalSurgery Today
Volume49
Issue number3
DOIs
Publication statusPublished - 08-03-2019
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery

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