A prospective study of human herpesvirus-6 infection in renal transplantation

Tetsushi Yoshikawa, Sadao Suga, Yoshizo Asano, Toshihiko Nakashima, Takehiko Yazaki, Yoshinari Ono, Tamio Fujita, Kazuo Tsuzuki, Satoshi Sugiyama, Shinichi Oshima

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Abstract

Sixty-five kidney transplant recipients and their (22 living related and 43 cadaveric) donors were studied prospectively to determine the relationship between kidney transplantation and human herpesvirus-6 (HHV-6) infection. The virus isolation from peripheral blood and other tissues and sequential determination of neutralizing antibodies to HHV-6 were performed during 3 months following the transplantation. All of the donors and their recipients examined had neutralizing antibodies to HHV-6 at the time of renal transplantation and the virus was not isolated from them. HHV-6 was isolated from 3 renal tissues (2 living related and 1 cadaveric) obtained during transplant surgery, but not from their blood at that time. HHV-6 viremia occurred in 9 (14%) of the 65 recipients around 2 to 4 weeks after the transplantation. An additional 27 recipients showed a significant rise in the antibody titer. Thus, the infection with HHV-6 was confirmed in 36 (55%) of the 65. These results indicate that the virus is activated in many cases in the early posttransplant period and that HHV-6 establishes in vivo latency in the kidney tissue. There was no correlation between HHV-6 infection and acute rejection or the antirejection prophylaxis.

Original languageEnglish
Pages (from-to)879-883
Number of pages5
JournalTransplantation
Volume54
Issue number5
Publication statusPublished - 01-01-1992

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Human Herpesvirus 6
Herpesviridae Infections
Kidney Transplantation
Prospective Studies
Viruses
Neutralizing Antibodies
Kidney
Transplantation
Tissue Donors
Viremia
Transplants
Antibodies

All Science Journal Classification (ASJC) codes

  • Transplantation

Cite this

Yoshikawa, T., Suga, S., Asano, Y., Nakashima, T., Yazaki, T., Ono, Y., ... Oshima, S. (1992). A prospective study of human herpesvirus-6 infection in renal transplantation. Transplantation, 54(5), 879-883.
Yoshikawa, Tetsushi ; Suga, Sadao ; Asano, Yoshizo ; Nakashima, Toshihiko ; Yazaki, Takehiko ; Ono, Yoshinari ; Fujita, Tamio ; Tsuzuki, Kazuo ; Sugiyama, Satoshi ; Oshima, Shinichi. / A prospective study of human herpesvirus-6 infection in renal transplantation. In: Transplantation. 1992 ; Vol. 54, No. 5. pp. 879-883.
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abstract = "Sixty-five kidney transplant recipients and their (22 living related and 43 cadaveric) donors were studied prospectively to determine the relationship between kidney transplantation and human herpesvirus-6 (HHV-6) infection. The virus isolation from peripheral blood and other tissues and sequential determination of neutralizing antibodies to HHV-6 were performed during 3 months following the transplantation. All of the donors and their recipients examined had neutralizing antibodies to HHV-6 at the time of renal transplantation and the virus was not isolated from them. HHV-6 was isolated from 3 renal tissues (2 living related and 1 cadaveric) obtained during transplant surgery, but not from their blood at that time. HHV-6 viremia occurred in 9 (14{\%}) of the 65 recipients around 2 to 4 weeks after the transplantation. An additional 27 recipients showed a significant rise in the antibody titer. Thus, the infection with HHV-6 was confirmed in 36 (55{\%}) of the 65. These results indicate that the virus is activated in many cases in the early posttransplant period and that HHV-6 establishes in vivo latency in the kidney tissue. There was no correlation between HHV-6 infection and acute rejection or the antirejection prophylaxis.",
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Yoshikawa, T, Suga, S, Asano, Y, Nakashima, T, Yazaki, T, Ono, Y, Fujita, T, Tsuzuki, K, Sugiyama, S & Oshima, S 1992, 'A prospective study of human herpesvirus-6 infection in renal transplantation', Transplantation, vol. 54, no. 5, pp. 879-883.

A prospective study of human herpesvirus-6 infection in renal transplantation. / Yoshikawa, Tetsushi; Suga, Sadao; Asano, Yoshizo; Nakashima, Toshihiko; Yazaki, Takehiko; Ono, Yoshinari; Fujita, Tamio; Tsuzuki, Kazuo; Sugiyama, Satoshi; Oshima, Shinichi.

In: Transplantation, Vol. 54, No. 5, 01.01.1992, p. 879-883.

Research output: Contribution to journalArticle

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AU - Yoshikawa, Tetsushi

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AU - Oshima, Shinichi

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N2 - Sixty-five kidney transplant recipients and their (22 living related and 43 cadaveric) donors were studied prospectively to determine the relationship between kidney transplantation and human herpesvirus-6 (HHV-6) infection. The virus isolation from peripheral blood and other tissues and sequential determination of neutralizing antibodies to HHV-6 were performed during 3 months following the transplantation. All of the donors and their recipients examined had neutralizing antibodies to HHV-6 at the time of renal transplantation and the virus was not isolated from them. HHV-6 was isolated from 3 renal tissues (2 living related and 1 cadaveric) obtained during transplant surgery, but not from their blood at that time. HHV-6 viremia occurred in 9 (14%) of the 65 recipients around 2 to 4 weeks after the transplantation. An additional 27 recipients showed a significant rise in the antibody titer. Thus, the infection with HHV-6 was confirmed in 36 (55%) of the 65. These results indicate that the virus is activated in many cases in the early posttransplant period and that HHV-6 establishes in vivo latency in the kidney tissue. There was no correlation between HHV-6 infection and acute rejection or the antirejection prophylaxis.

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Yoshikawa T, Suga S, Asano Y, Nakashima T, Yazaki T, Ono Y et al. A prospective study of human herpesvirus-6 infection in renal transplantation. Transplantation. 1992 Jan 1;54(5):879-883.