A prospective study of reproductive and menstrual factors and colon cancer risk in Japanese women: Findings from the JACC study

Koji Tamakoshi, Kenji Wakai, Masayo Kojima, Yoshiyuki Watanabe, Norihiko Hayakawa, Hideaki Toyoshima, Hiroshi Yatsuya, Takaaki Kondo, Shinkan Tokudome, Shuji Hashimoto, Koji Suzuki, Sadao Suzuki, Miyuki Kawado, Kotaro Ozasa, Yoshinori Ito, Akiko Tamakoshi, Mitsuru Mori, Yutaka Motohashi, Ichiro Tsuji, Yosikazu NakamuraHiroyasu Iso, Haruo Mikami, Yutaka Inaba, Yoshiharu Hoshiyama, Hiroshi Suzuki, Hiroyuki Shimizu, Shinkan Tokudeme, Shogo Kikuchi, Akio Koizumi, Takashi Kawamura, Tsuneharu Miki, Chigusa Date, Kiyomi Sakata, Takayuki Nose, Takesumi Yoshimura, Katsuhiro Fukuda, Naoyuki Okamoto, Hideo Shio, Yoshiyuki Ohno, Tomoyuki Kitagawa, Toshio Kuroki, Kazuo Tajima

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The effects of reproductive factors on the etiology of colon cancer in Asian populations remain unexplored. So we examined 38,420 Japanese women aged 40-79 years who responded to a questionnaire on reproductive and other lifestyle factors from 1988 to 1990 in the Japan Collaborative Cohort Study for Evaluation of Cancer Risk. During an average 7.6 years of follow-up, we documented 207 incident colon cancers. Multivariate analysis indicated that colon cancer risk was likely to be lower among parous women than among nulliparous. Women who had two abortions or more had a 72% higher risk of developing colon cancer [relative risk (RR) 1.72; 95% confidence interval (CI) 1.16-2.55; trend P<0.01] compared with women who never had an abortion. The RR of colon cancer among postmenopausal women significantly decreased with increasing age at menarche (trend P=0.01). No apparent association between colon cancer and gravida, age at first birth, age at menopause, or duration of menstruation was seen. These prospective data support the hypothesis that female reproductive events modify colon cancer risk, and suggest that reproductive factors, particularly age at menarche and having an abortion, may be of importance in the etiology of colon cancer among Japanese women.

Original languageEnglish
Pages (from-to)602-607
Number of pages6
JournalCancer Science
Volume95
Issue number7
DOIs
Publication statusPublished - 01-07-2004

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Colonic Neoplasms
Prospective Studies
Menarche
Birth Order
Menstruation
Age Factors
Menopause
Life Style
Japan
Cohort Studies
Multivariate Analysis
Confidence Intervals
Population
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Tamakoshi, Koji ; Wakai, Kenji ; Kojima, Masayo ; Watanabe, Yoshiyuki ; Hayakawa, Norihiko ; Toyoshima, Hideaki ; Yatsuya, Hiroshi ; Kondo, Takaaki ; Tokudome, Shinkan ; Hashimoto, Shuji ; Suzuki, Koji ; Suzuki, Sadao ; Kawado, Miyuki ; Ozasa, Kotaro ; Ito, Yoshinori ; Tamakoshi, Akiko ; Mori, Mitsuru ; Motohashi, Yutaka ; Tsuji, Ichiro ; Nakamura, Yosikazu ; Iso, Hiroyasu ; Mikami, Haruo ; Inaba, Yutaka ; Hoshiyama, Yoshiharu ; Suzuki, Hiroshi ; Shimizu, Hiroyuki ; Tokudeme, Shinkan ; Kikuchi, Shogo ; Koizumi, Akio ; Kawamura, Takashi ; Miki, Tsuneharu ; Date, Chigusa ; Sakata, Kiyomi ; Nose, Takayuki ; Yoshimura, Takesumi ; Fukuda, Katsuhiro ; Okamoto, Naoyuki ; Shio, Hideo ; Ohno, Yoshiyuki ; Kitagawa, Tomoyuki ; Kuroki, Toshio ; Tajima, Kazuo. / A prospective study of reproductive and menstrual factors and colon cancer risk in Japanese women : Findings from the JACC study. In: Cancer Science. 2004 ; Vol. 95, No. 7. pp. 602-607.
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abstract = "The effects of reproductive factors on the etiology of colon cancer in Asian populations remain unexplored. So we examined 38,420 Japanese women aged 40-79 years who responded to a questionnaire on reproductive and other lifestyle factors from 1988 to 1990 in the Japan Collaborative Cohort Study for Evaluation of Cancer Risk. During an average 7.6 years of follow-up, we documented 207 incident colon cancers. Multivariate analysis indicated that colon cancer risk was likely to be lower among parous women than among nulliparous. Women who had two abortions or more had a 72{\%} higher risk of developing colon cancer [relative risk (RR) 1.72; 95{\%} confidence interval (CI) 1.16-2.55; trend P<0.01] compared with women who never had an abortion. The RR of colon cancer among postmenopausal women significantly decreased with increasing age at menarche (trend P=0.01). No apparent association between colon cancer and gravida, age at first birth, age at menopause, or duration of menstruation was seen. These prospective data support the hypothesis that female reproductive events modify colon cancer risk, and suggest that reproductive factors, particularly age at menarche and having an abortion, may be of importance in the etiology of colon cancer among Japanese women.",
author = "Koji Tamakoshi and Kenji Wakai and Masayo Kojima and Yoshiyuki Watanabe and Norihiko Hayakawa and Hideaki Toyoshima and Hiroshi Yatsuya and Takaaki Kondo and Shinkan Tokudome and Shuji Hashimoto and Koji Suzuki and Sadao Suzuki and Miyuki Kawado and Kotaro Ozasa and Yoshinori Ito and Akiko Tamakoshi and Mitsuru Mori and Yutaka Motohashi and Ichiro Tsuji and Yosikazu Nakamura and Hiroyasu Iso and Haruo Mikami and Yutaka Inaba and Yoshiharu Hoshiyama and Hiroshi Suzuki and Hiroyuki Shimizu and Shinkan Tokudeme and Shogo Kikuchi and Akio Koizumi and Takashi Kawamura and Tsuneharu Miki and Chigusa Date and Kiyomi Sakata and Takayuki Nose and Takesumi Yoshimura and Katsuhiro Fukuda and Naoyuki Okamoto and Hideo Shio and Yoshiyuki Ohno and Tomoyuki Kitagawa and Toshio Kuroki and Kazuo Tajima",
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Tamakoshi, K, Wakai, K, Kojima, M, Watanabe, Y, Hayakawa, N, Toyoshima, H, Yatsuya, H, Kondo, T, Tokudome, S, Hashimoto, S, Suzuki, K, Suzuki, S, Kawado, M, Ozasa, K, Ito, Y, Tamakoshi, A, Mori, M, Motohashi, Y, Tsuji, I, Nakamura, Y, Iso, H, Mikami, H, Inaba, Y, Hoshiyama, Y, Suzuki, H, Shimizu, H, Tokudeme, S, Kikuchi, S, Koizumi, A, Kawamura, T, Miki, T, Date, C, Sakata, K, Nose, T, Yoshimura, T, Fukuda, K, Okamoto, N, Shio, H, Ohno, Y, Kitagawa, T, Kuroki, T & Tajima, K 2004, 'A prospective study of reproductive and menstrual factors and colon cancer risk in Japanese women: Findings from the JACC study', Cancer Science, vol. 95, no. 7, pp. 602-607. https://doi.org/10.1111/j.1349-7006.2004.tb02494.x

A prospective study of reproductive and menstrual factors and colon cancer risk in Japanese women : Findings from the JACC study. / Tamakoshi, Koji; Wakai, Kenji; Kojima, Masayo; Watanabe, Yoshiyuki; Hayakawa, Norihiko; Toyoshima, Hideaki; Yatsuya, Hiroshi; Kondo, Takaaki; Tokudome, Shinkan; Hashimoto, Shuji; Suzuki, Koji; Suzuki, Sadao; Kawado, Miyuki; Ozasa, Kotaro; Ito, Yoshinori; Tamakoshi, Akiko; Mori, Mitsuru; Motohashi, Yutaka; Tsuji, Ichiro; Nakamura, Yosikazu; Iso, Hiroyasu; Mikami, Haruo; Inaba, Yutaka; Hoshiyama, Yoshiharu; Suzuki, Hiroshi; Shimizu, Hiroyuki; Tokudeme, Shinkan; Kikuchi, Shogo; Koizumi, Akio; Kawamura, Takashi; Miki, Tsuneharu; Date, Chigusa; Sakata, Kiyomi; Nose, Takayuki; Yoshimura, Takesumi; Fukuda, Katsuhiro; Okamoto, Naoyuki; Shio, Hideo; Ohno, Yoshiyuki; Kitagawa, Tomoyuki; Kuroki, Toshio; Tajima, Kazuo.

In: Cancer Science, Vol. 95, No. 7, 01.07.2004, p. 602-607.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A prospective study of reproductive and menstrual factors and colon cancer risk in Japanese women

T2 - Findings from the JACC study

AU - Tamakoshi, Koji

AU - Wakai, Kenji

AU - Kojima, Masayo

AU - Watanabe, Yoshiyuki

AU - Hayakawa, Norihiko

AU - Toyoshima, Hideaki

AU - Yatsuya, Hiroshi

AU - Kondo, Takaaki

AU - Tokudome, Shinkan

AU - Hashimoto, Shuji

AU - Suzuki, Koji

AU - Suzuki, Sadao

AU - Kawado, Miyuki

AU - Ozasa, Kotaro

AU - Ito, Yoshinori

AU - Tamakoshi, Akiko

AU - Mori, Mitsuru

AU - Motohashi, Yutaka

AU - Tsuji, Ichiro

AU - Nakamura, Yosikazu

AU - Iso, Hiroyasu

AU - Mikami, Haruo

AU - Inaba, Yutaka

AU - Hoshiyama, Yoshiharu

AU - Suzuki, Hiroshi

AU - Shimizu, Hiroyuki

AU - Tokudeme, Shinkan

AU - Kikuchi, Shogo

AU - Koizumi, Akio

AU - Kawamura, Takashi

AU - Miki, Tsuneharu

AU - Date, Chigusa

AU - Sakata, Kiyomi

AU - Nose, Takayuki

AU - Yoshimura, Takesumi

AU - Fukuda, Katsuhiro

AU - Okamoto, Naoyuki

AU - Shio, Hideo

AU - Ohno, Yoshiyuki

AU - Kitagawa, Tomoyuki

AU - Kuroki, Toshio

AU - Tajima, Kazuo

PY - 2004/7/1

Y1 - 2004/7/1

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AB - The effects of reproductive factors on the etiology of colon cancer in Asian populations remain unexplored. So we examined 38,420 Japanese women aged 40-79 years who responded to a questionnaire on reproductive and other lifestyle factors from 1988 to 1990 in the Japan Collaborative Cohort Study for Evaluation of Cancer Risk. During an average 7.6 years of follow-up, we documented 207 incident colon cancers. Multivariate analysis indicated that colon cancer risk was likely to be lower among parous women than among nulliparous. Women who had two abortions or more had a 72% higher risk of developing colon cancer [relative risk (RR) 1.72; 95% confidence interval (CI) 1.16-2.55; trend P<0.01] compared with women who never had an abortion. The RR of colon cancer among postmenopausal women significantly decreased with increasing age at menarche (trend P=0.01). No apparent association between colon cancer and gravida, age at first birth, age at menopause, or duration of menstruation was seen. These prospective data support the hypothesis that female reproductive events modify colon cancer risk, and suggest that reproductive factors, particularly age at menarche and having an abortion, may be of importance in the etiology of colon cancer among Japanese women.

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