Abstract
Fibronectin glomerulopathy (FNG) is a rare, autosomal dominant renal disease with massive mesangial, and subendothelial fibronectin deposits. It presents proteinuria, often in the nephrotic range in the third to fourth decade, and slow progression to end-stage renal disease. The risk of recurrent disease in renal allograft is uncertain. A Japanese female with end-stage renal disease because of unknown origin received a renal transplant and was referred with proteinuria and mild deterioration of renal function four months after transplantation. Five allograft biopsies were underwent from one h to 12 months after the transplantation, including a biopsy 19 d after the transplantation, which revealed dense deposits suggesting fibronectin. A biopsy 134 d after the transplantation showed a feature of lobular glomerulonephritis corresponding FNG. The diagnosis was confirmed by IST4 positive and IST9 negative immunostaining together with typical fibrillary dense deposits in the mesangium and subendothelial spaces in electron microscopy. This is the first report of recurrent FNG in Japan.
| Original language | English |
|---|---|
| Pages (from-to) | 58-63 |
| Number of pages | 6 |
| Journal | Clinical Transplantation |
| Volume | 26 |
| Issue number | SUPPL.24 |
| DOIs | |
| Publication status | Published - 01-07-2012 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Transplantation
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A recurrent fibronectin glomerulopathy in a renal transplant patient : A case report. / Otsuka, Yasuhiro; Takeda, Asami; Horike, Keiji; Inaguma, Daijo; Goto, Norihiko; Watarai, Yoshihiko; Uchida, Kazuharu; Mihatsch, Michael J.; Joh, Kensuke; Morozumi, Kunio.
In: Clinical Transplantation, Vol. 26, No. SUPPL.24, 01.07.2012, p. 58-63.Research output: Contribution to journal › Article
TY - JOUR
T1 - A recurrent fibronectin glomerulopathy in a renal transplant patient
T2 - A case report
AU - Otsuka, Yasuhiro
AU - Takeda, Asami
AU - Horike, Keiji
AU - Inaguma, Daijo
AU - Goto, Norihiko
AU - Watarai, Yoshihiko
AU - Uchida, Kazuharu
AU - Mihatsch, Michael J.
AU - Joh, Kensuke
AU - Morozumi, Kunio
PY - 2012/7/1
Y1 - 2012/7/1
N2 - Fibronectin glomerulopathy (FNG) is a rare, autosomal dominant renal disease with massive mesangial, and subendothelial fibronectin deposits. It presents proteinuria, often in the nephrotic range in the third to fourth decade, and slow progression to end-stage renal disease. The risk of recurrent disease in renal allograft is uncertain. A Japanese female with end-stage renal disease because of unknown origin received a renal transplant and was referred with proteinuria and mild deterioration of renal function four months after transplantation. Five allograft biopsies were underwent from one h to 12 months after the transplantation, including a biopsy 19 d after the transplantation, which revealed dense deposits suggesting fibronectin. A biopsy 134 d after the transplantation showed a feature of lobular glomerulonephritis corresponding FNG. The diagnosis was confirmed by IST4 positive and IST9 negative immunostaining together with typical fibrillary dense deposits in the mesangium and subendothelial spaces in electron microscopy. This is the first report of recurrent FNG in Japan.
AB - Fibronectin glomerulopathy (FNG) is a rare, autosomal dominant renal disease with massive mesangial, and subendothelial fibronectin deposits. It presents proteinuria, often in the nephrotic range in the third to fourth decade, and slow progression to end-stage renal disease. The risk of recurrent disease in renal allograft is uncertain. A Japanese female with end-stage renal disease because of unknown origin received a renal transplant and was referred with proteinuria and mild deterioration of renal function four months after transplantation. Five allograft biopsies were underwent from one h to 12 months after the transplantation, including a biopsy 19 d after the transplantation, which revealed dense deposits suggesting fibronectin. A biopsy 134 d after the transplantation showed a feature of lobular glomerulonephritis corresponding FNG. The diagnosis was confirmed by IST4 positive and IST9 negative immunostaining together with typical fibrillary dense deposits in the mesangium and subendothelial spaces in electron microscopy. This is the first report of recurrent FNG in Japan.
UR - http://www.scopus.com/inward/record.url?scp=84863212743&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84863212743&partnerID=8YFLogxK
U2 - 10.1111/j.1399-0012.2012.01644.x
DO - 10.1111/j.1399-0012.2012.01644.x
M3 - Article
C2 - 22747478
AN - SCOPUS:84863212743
VL - 26
SP - 58
EP - 63
JO - Clinical Transplantation
JF - Clinical Transplantation
SN - 0902-0063
IS - SUPPL.24
ER -