A refractory duodenal ulcer with a biliar

Yohei Horibe, Seiji AdAchi, Mitsuru Okuno, Tomohiko Ohno, Naoe Goto, Midori Iwama, Osamu Yamauchi, Koshiro Saito, Ichiro Yasuda, Masahito Shimizu

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


A 65-year-oId woman with recurrent breast cancer was repeatedly treated with bevacizumab, an anti-VEGF antibody. In addition, she was also frequently prescribed a nonsteroidal anti-inflammatory drug for abdominal pain. Melena was revealed 2 months after the final treatment with bevacizumab, and an endoscopic study revealed a duodenal ulcer (DU) that was resistant to anti-ulcer therapy. A cholangiography identified a biliary-duodenal fistula with bile juice leaking from the ulcer base. Therefore, a biliary stent was placed into the common bile duct for 3 months until the DU healed. This is the first case of a refractory DU with a biliary-duodenal fistula in a patient treated with bevacizumab.

Original languageEnglish
Pages (from-to)1244-1250
Number of pages7
JournalJournal of Japanese Society of Gastroenterology
Issue number7
Publication statusPublished - 07-2016

All Science Journal Classification (ASJC) codes

  • Gastroenterology


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