We report what is, to our knowledge, only the third reported case of double hepatocellular carcinoma (HCC) and cholangiolocellular carcinoma (CoCC). A 64-year-old man with positive hepatitis B virus (HBV) liver cirrhosis hospitalized for hepatic lesions had elevated plasma AFP and PIVKA-II. Abdominal computed tomography (CT) and magnetic resonance imaging (MRI) showed hypervascular nodules at S8a and S8c, necessitating partial hepatic resections. Histologically, the S8a tumor was HCC and the S8c tumor CoCC.
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