A retrospective multicenter study of sublingual gland carcinoma in Japan

Tsuyoshi Kojima, Ryusuke Hori, Shinzo Tanaka, Hisanobu Tamaki, Ryo Asato, Morimasa Kitamura, Ichiro Tateya, Shogo Shinohara, Shinji Takebayashi, Toshiki Maetani, Yoshiharu Kitani, Yohei Kumabe, Koji Ushiro, Kazuyuki Ichimaru, Keigo Honda, Masanobu Mizuta, Koichiro Yamada, Koichi Omori

Research output: Contribution to journalArticle

Abstract

Objective: Salivary gland carcinoma is rare among head and neck cancers. Sublingual gland carcinoma, a type of salivary gland carcinoma, is even rarer; therefore, the number of cases at a single institute is too small for sufficient evaluation of tumor characteristics. We conducted a multicenter, retrospective analysis of sublingual gland carcinomas in patients who visited 12 institutions associated with the Kyoto Hospital and Affiliated Facilities Head and Neck Clinical Oncology Group. Methods: Thirteen previously untreated patients who visited the institutions between 2006 and 2015 were enrolled. The overall survival (OS) and disease-free survival (DFS) rates for all patients and by disease stage were analyzed. Statistical analyses were performed for all patients with respect to disease stage. Results: Eight of thirteen patients were diagnosed with adenoid cystic carcinoma on pathological study. A significant difference in OS rate was observed between patients with Stage I–III and Stage IV disease; however, the difference in DFS rate by disease stage was not significant. Conclusion: Stage IV disease was identified as a poor prognostic factor in patients with sublingual gland carcinoma. However, even patients with Stage I–III disease experienced relatively short DFS. Distant metastasis is a serious problem among patients with sublingual gland carcinoma.

Original languageEnglish
Pages (from-to)111-115
Number of pages5
JournalAuris Nasus Larynx
Volume47
Issue number1
DOIs
Publication statusPublished - 02-2020
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Otorhinolaryngology

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  • Cite this

    Kojima, T., Hori, R., Tanaka, S., Tamaki, H., Asato, R., Kitamura, M., Tateya, I., Shinohara, S., Takebayashi, S., Maetani, T., Kitani, Y., Kumabe, Y., Ushiro, K., Ichimaru, K., Honda, K., Mizuta, M., Yamada, K., & Omori, K. (2020). A retrospective multicenter study of sublingual gland carcinoma in Japan. Auris Nasus Larynx, 47(1), 111-115. https://doi.org/10.1016/j.anl.2019.04.006