TY - JOUR
T1 - A retrospective study on hormone replacement therapy after ovarian cancer surgery at our hospital
AU - Kobayashi, Arata
AU - Nomura, Hiroyuki
AU - Takada, Kyohei
AU - Owaki, Akiko
AU - Ito, Mayuko
AU - Ichikawa, Ryoko
AU - Noda, Yoshiteru
AU - Miyamura, Hironori
AU - Nishio, Eiji
AU - Nishizawa, Haruki
N1 - Publisher Copyright:
© 2025 Arata Kobayashi, MD et al.
PY - 2025
Y1 - 2025
N2 - Objectives: Hormone replacement therapy (HRT) is considered for ovarian cancer patients who develop menopausal symptoms, dyslipidemia, and osteoporosis due to iatrogenic menopause caused by surgery or anticancer drug treatment. However, there have been few reports on HRT administration methods and those that evaluate cancer recurrence and complications of HRT. Methods: We examined the administration method, adverse reactions and cancer recurrence in 28 patients who received HRT after ovarian cancer surgery at our hospital. Results: All patients received estradiol monotherapy, and cancer recurrence was observed in four patients (14.3%); adverse reactions included skin eruption in two patients (7.1%), there were no other serious adverse reactions noted. Conclusion: The method and duration of HRT administration and the timing of HRT discontinuation remain debated. Thus, a large-scale survey and standardization of HRT administration methods after ovarian cancer surgery in Japan are needed.
AB - Objectives: Hormone replacement therapy (HRT) is considered for ovarian cancer patients who develop menopausal symptoms, dyslipidemia, and osteoporosis due to iatrogenic menopause caused by surgery or anticancer drug treatment. However, there have been few reports on HRT administration methods and those that evaluate cancer recurrence and complications of HRT. Methods: We examined the administration method, adverse reactions and cancer recurrence in 28 patients who received HRT after ovarian cancer surgery at our hospital. Results: All patients received estradiol monotherapy, and cancer recurrence was observed in four patients (14.3%); adverse reactions included skin eruption in two patients (7.1%), there were no other serious adverse reactions noted. Conclusion: The method and duration of HRT administration and the timing of HRT discontinuation remain debated. Thus, a large-scale survey and standardization of HRT administration methods after ovarian cancer surgery in Japan are needed.
KW - Hormone replacement therapy
KW - Iatrogenic menopause
KW - Ovarian cancer
UR - https://www.scopus.com/pages/publications/105022210465
UR - https://www.scopus.com/pages/publications/105022210465#tab=citedBy
U2 - 10.20407/fmj.2024-028
DO - 10.20407/fmj.2024-028
M3 - Article
AN - SCOPUS:105022210465
SN - 2189-7247
VL - 11
SP - 151
EP - 154
JO - Fujita Medical Journal
JF - Fujita Medical Journal
IS - 4
ER -
