A revised scheme for developmental pathways of hematopoietic cells: The myeloid-based model

Hiroshi Kawamoto, Haruka Wada, Yoshimoto Katsura

Research output: Contribution to journalReview articlepeer-review

30 Citations (Scopus)

Abstract

Blood cells comprise very diverse cell types with a wide range of crucial functions; however, they share a common progenitor cell type-the hematopoietic stem cell (HSC). Clarifying how HSCs differentiate into these diverse cell types is important for understanding how they attain their various functions and offers the potential for therapeutic manipulation. Various theories exist about how HSCs diversify; in particular, one model (the 'classical' model) proposes that lymphocytes and myeloerythroid lineages branch separately at an early stage of hematopoiesis, whereas another model (the 'myeloid-based' model) proposes that the myeloid potential is retained for much longer among cells that can become lymphocytes. This article describes and compares these models and outlines recent evidence supporting the myeloid-based model.

Original languageEnglish
Article numberdxp125
Pages (from-to)65-70
Number of pages6
JournalInternational Immunology
Volume22
Issue number2
DOIs
Publication statusPublished - 06-01-2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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