A role of anti-verotoxin antibody immunoreactive peptide, Virp5, from rat spinal cord

Naohisa Ishikawa; Guo Gang Feng; Yoshitake Ito; Yoshihiro Hotta; Yasushi Wakida; Hidetsugu Murakami; Michio Yajima; Atsuko Ishikawa; Takashi Yokochi

doi:10.1016/j.peptides.2004.06.017

A role of anti-verotoxin antibody immunoreactive peptide, Virp5, from rat spinal cord

Naohisa Ishikawa, Guo Gang Feng, Yoshitake Ito, Yoshihiro Hotta, Yasushi Wakida, Hidetsugu Murakami, Michio Yajima, Atsuko Ishikawa, Takashi Yokochi

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

An anti-verotoxin 2 (VT2) antibody immunoreactive 5-kDa polypeptide (Virp5), has been obtained through screening of the rat spinal cord cDNA library with the aid of anti-VT2 antibody. Virp5 was mainly expressed in the central nervous system, liver and kidney, and localized at glia-like cells and nerve fibers in the central nervous system, vascular endothelial cells and hepatic cells in the liver, as well as epithelial cells of distal tubules in the kidney. Intravenous administration of purified Virp5 elicited a dose-dependent increase in blood pressure. These results suggest that Virp5 commonly exists in the body, being partly playing a role in regulating the blood pressure.

Original language	English
Pages (from-to)	1909-1916
Number of pages	8
Journal	Peptides
Volume	25
Issue number	11
DOIs	https://doi.org/10.1016/j.peptides.2004.06.017
Publication status	Published - 11-2004
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Physiology
Endocrinology
Cellular and Molecular Neuroscience

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10.1016/j.peptides.2004.06.017

Cite this

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title = "A role of anti-verotoxin antibody immunoreactive peptide, Virp5, from rat spinal cord",

abstract = "An anti-verotoxin 2 (VT2) antibody immunoreactive 5-kDa polypeptide (Virp5), has been obtained through screening of the rat spinal cord cDNA library with the aid of anti-VT2 antibody. Virp5 was mainly expressed in the central nervous system, liver and kidney, and localized at glia-like cells and nerve fibers in the central nervous system, vascular endothelial cells and hepatic cells in the liver, as well as epithelial cells of distal tubules in the kidney. Intravenous administration of purified Virp5 elicited a dose-dependent increase in blood pressure. These results suggest that Virp5 commonly exists in the body, being partly playing a role in regulating the blood pressure.",

keywords = "Spinal cord, Vascular endothelial cell, Verotoxin 2, Virp5",

author = "Naohisa Ishikawa and Feng, \{Guo Gang\} and Yoshitake Ito and Yoshihiro Hotta and Yasushi Wakida and Hidetsugu Murakami and Michio Yajima and Atsuko Ishikawa and Takashi Yokochi",

year = "2004",

month = nov,

doi = "10.1016/j.peptides.2004.06.017",

language = "English",

volume = "25",

pages = "1909--1916",

journal = "Peptides",

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publisher = "Elsevier Inc.",

number = "11",

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TY - JOUR

T1 - A role of anti-verotoxin antibody immunoreactive peptide, Virp5, from rat spinal cord

AU - Ishikawa, Naohisa

AU - Feng, Guo Gang

AU - Ito, Yoshitake

AU - Hotta, Yoshihiro

AU - Wakida, Yasushi

AU - Murakami, Hidetsugu

AU - Yajima, Michio

AU - Ishikawa, Atsuko

AU - Yokochi, Takashi

PY - 2004/11

Y1 - 2004/11

N2 - An anti-verotoxin 2 (VT2) antibody immunoreactive 5-kDa polypeptide (Virp5), has been obtained through screening of the rat spinal cord cDNA library with the aid of anti-VT2 antibody. Virp5 was mainly expressed in the central nervous system, liver and kidney, and localized at glia-like cells and nerve fibers in the central nervous system, vascular endothelial cells and hepatic cells in the liver, as well as epithelial cells of distal tubules in the kidney. Intravenous administration of purified Virp5 elicited a dose-dependent increase in blood pressure. These results suggest that Virp5 commonly exists in the body, being partly playing a role in regulating the blood pressure.

AB - An anti-verotoxin 2 (VT2) antibody immunoreactive 5-kDa polypeptide (Virp5), has been obtained through screening of the rat spinal cord cDNA library with the aid of anti-VT2 antibody. Virp5 was mainly expressed in the central nervous system, liver and kidney, and localized at glia-like cells and nerve fibers in the central nervous system, vascular endothelial cells and hepatic cells in the liver, as well as epithelial cells of distal tubules in the kidney. Intravenous administration of purified Virp5 elicited a dose-dependent increase in blood pressure. These results suggest that Virp5 commonly exists in the body, being partly playing a role in regulating the blood pressure.

KW - Spinal cord

KW - Vascular endothelial cell

KW - Verotoxin 2

KW - Virp5

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DO - 10.1016/j.peptides.2004.06.017

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SN - 0196-9781

VL - 25

SP - 1909

EP - 1916

JO - Peptides

JF - Peptides

IS - 11

ER -

A role of anti-verotoxin antibody immunoreactive peptide, Virp5, from rat spinal cord

Abstract

All Science Journal Classification (ASJC) codes

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