TY - JOUR
T1 - A significance of school screening electrocardiogram in the patients with ventricular noncompaction
AU - Study group on childhood cardiomyopathy in Japan
AU - Hirono, Keiichi
AU - Miyao, Nariaki
AU - Yoshinaga, Masao
AU - Nishihara, Eiki
AU - Yasuda, Kazushi
AU - Tateno, Shigeru
AU - Ayusawa, Mamoru
AU - Sumitomo, Naokata
AU - Horigome, Hitoshi
AU - Iwamoto, Mari
AU - Takahashi, Hideto
AU - Sato, Seiichi
AU - Kogaki, Shigetoyo
AU - Ohno, Seiko
AU - Hata, Tadayoshi
AU - Hazeki, Daisuke
AU - Izumida, Naomi
AU - Nagashima, Masami
AU - Ohta, Kunio
AU - Tauchi, Nobuo
AU - Ushinohama, Hiroya
AU - Doi, Shozaburo
AU - Ichida, Fukiko
N1 - Funding Information:
This study was partly supported by Health and Labour Sciences Research Grants from the Ministry of Health, Labour and Welfare of Japan (H26-002, H29-034).
Funding Information:
The authors wish to acknowledge to Hitoshi Moriuchi, Haruna Hirai and Eriko Masuda for their expert technical assistance. The authors gratefully thank Shinya Takarada, Mako Okabe, Hideyuki Nakaoka, Keijiro Ibuki, and Sayaka Ozawa for their great assistance.
PY - 2020/7/1
Y1 - 2020/7/1
N2 - Left ventricular noncompaction (LVNC) is a hereditary cardiomyopathy and is associated with high morbidity and mortality. However, the role and significance of school screening for LVNC have not been fully elucidated. In this multicenter, retrospective cohort study, a total of 105 children with LVNC were included from 2000 to 2017. At the initial presentation, 44 patients (41.9%) were diagnosed by school screening. One (1.0%) patient underwent heart transplantation and four (3.8%) patients died during the study. Electrocardiogram data showed a high prevalence of fragmented QRS (33.4%) and J wave (15.7%). Treatments were needed in eight (18.2%) patients who were detected by school screening. The multivariable proportional hazards model showed T-wave abnormality on electrocardiogram in first graders was independent risk factors for major adverse cardiac events (odds ratio 4.94, p value = 0.0007). Moreover, dilation of the left atrium on chest X-ray and low ejection fraction on echocardiogram at the initial treatment were independent risk factors for treatment (odds ratio 1.7 × 107 and 22.3, p = 0.0362 and 0.0028, respectively). This study is the first report focusing on school screening in a large pediatric cohort with LVNC. With the use of abnormalities in electrocardiogram, school screening may be a good detector of and predictor for LVNC.
AB - Left ventricular noncompaction (LVNC) is a hereditary cardiomyopathy and is associated with high morbidity and mortality. However, the role and significance of school screening for LVNC have not been fully elucidated. In this multicenter, retrospective cohort study, a total of 105 children with LVNC were included from 2000 to 2017. At the initial presentation, 44 patients (41.9%) were diagnosed by school screening. One (1.0%) patient underwent heart transplantation and four (3.8%) patients died during the study. Electrocardiogram data showed a high prevalence of fragmented QRS (33.4%) and J wave (15.7%). Treatments were needed in eight (18.2%) patients who were detected by school screening. The multivariable proportional hazards model showed T-wave abnormality on electrocardiogram in first graders was independent risk factors for major adverse cardiac events (odds ratio 4.94, p value = 0.0007). Moreover, dilation of the left atrium on chest X-ray and low ejection fraction on echocardiogram at the initial treatment were independent risk factors for treatment (odds ratio 1.7 × 107 and 22.3, p = 0.0362 and 0.0028, respectively). This study is the first report focusing on school screening in a large pediatric cohort with LVNC. With the use of abnormalities in electrocardiogram, school screening may be a good detector of and predictor for LVNC.
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U2 - 10.1007/s00380-020-01571-7
DO - 10.1007/s00380-020-01571-7
M3 - Article
C2 - 32161993
AN - SCOPUS:85081627492
VL - 35
SP - 985
EP - 995
JO - Heart and Vessels
JF - Heart and Vessels
SN - 0910-8327
IS - 7
ER -