A single amino acid substitution in the ICP27 protein of herpes simplex virus type 1 is responsible for its resistance to leptomycin B

T. Murata, F. Goshima, T. Koshizuka, H. Takakuwa, Y. Nishiyama

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Abstract

Leptomycin B (LMB) is a specific inhibitor of Crm1-dependent nuclear export of proteins. The replication of herpes simplex virus (HSV) is normally highly sensitive to LMB; a resistant HSV variant, however, was isolated by serial passages of the virus. Analysis of marker transfer and viral DNA sequences revealed that a single amino acid substitution within the ICP27 gene is responsible for conferring this resistance.

Original languageEnglish
Pages (from-to)1039-1043
Number of pages5
JournalJournal of Virology
Volume75
Issue number2
DOIs
Publication statusPublished - 16-01-2001

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All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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