Abstract
Leptomycin B (LMB) is a specific inhibitor of Crm1-dependent nuclear export of proteins. The replication of herpes simplex virus (HSV) is normally highly sensitive to LMB; a resistant HSV variant, however, was isolated by serial passages of the virus. Analysis of marker transfer and viral DNA sequences revealed that a single amino acid substitution within the ICP27 gene is responsible for conferring this resistance.
Original language | English |
---|---|
Pages (from-to) | 1039-1043 |
Number of pages | 5 |
Journal | Journal of Virology |
Volume | 75 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2001 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Microbiology
- Immunology
- Insect Science
- Virology