A single exposure of rats to water-immersion restraint stress induces oxidative stress more severely in the thymus than in the spleen

Yoshiji Ohta, Koji Yashiro, Mayumi Hidaka, Minako Honda, Yoichoro Imai, Koji Ohashi, Kenji Fukuzawa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives: We examined whether a single exposure of rats to water-immersion restraint stress (WIRS) induces oxidative stress in the thymus and spleen. Methods: Vitamin E, ascorbic acid, reduced glutathione (GSH), and lipid peroxide (LPO) were assayed in the thymus and spleen of rats with and without 6 hours of WIRS. Results: In unstressed rats, vitamin E, ascorbic acid, GSH, and LPO levels were higher in the thymus than in the spleen. Thymic ascorbic acid level was lower in stressed rats than in unstressed rats. Splenic ascorbic acid level was similar in both groups. Thymic and splenic GSH levels were lower in stressed rats than in unstressed rats but the reduced amount of GSH was lower in the spleen than in the thymus. Thymic vitamin E level was lower in stressed than in unstressed rats. Splenic vitamin E level was higher in stressed rats than in unstressed rats. Thymic and splenic LPO levels were higher in stressed rats than in unstressed rats but the increased amount of LPO was higher in the thymus than in the spleen. Conclusion: It is indicated that a single expose of rats to WIRS induces oxidative stress more severely in the thymus than in the spleen.

Original languageEnglish
Pages (from-to)200-205
Number of pages6
JournalRedox Report
Volume17
Issue number5
DOIs
Publication statusPublished - 01-09-2012

Fingerprint

Thymus
Oxidative stress
Immersion
Thymus Gland
Rats
Oxidative Stress
Spleen
Water
Lipid Peroxides
Vitamin E
Ascorbic Acid
Glutathione

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical

Cite this

Ohta, Yoshiji ; Yashiro, Koji ; Hidaka, Mayumi ; Honda, Minako ; Imai, Yoichoro ; Ohashi, Koji ; Fukuzawa, Kenji. / A single exposure of rats to water-immersion restraint stress induces oxidative stress more severely in the thymus than in the spleen. In: Redox Report. 2012 ; Vol. 17, No. 5. pp. 200-205.
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A single exposure of rats to water-immersion restraint stress induces oxidative stress more severely in the thymus than in the spleen. / Ohta, Yoshiji; Yashiro, Koji; Hidaka, Mayumi; Honda, Minako; Imai, Yoichoro; Ohashi, Koji; Fukuzawa, Kenji.

In: Redox Report, Vol. 17, No. 5, 01.09.2012, p. 200-205.

Research output: Contribution to journalArticle

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