A single nucleotide polymorphism of IL-17 gene in the recipient is associated with acute GVHD after HLA-matched unrelated BMT

J. L. Espinoza, A. Takami, M. Onizuka, T. Kawase, H. Sao, H. Akiyama, K. Miyamura, S. Okamoto, M. Inoue, S. Ohtake, T. Fukuda, Y. Morishima, Y. Kodera, S. Nakao

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

IL-17 has an important role in the host defense against extracellular pathogens and the pathophysiology of autoimmune diseases. This study retrospectively examined the impact of a single-nucleotide polymorphism (rs2275913, G197A) in the IL-17 gene of a total 510 recipients with hematologic malignancies and their unrelated donors on the clinical outcomes in HLA-matched myeloablative (discovery study) and nonmyeloablative (validation study) BMT through the Japan Marrow Donor Program (JMDP). In the discovery study, the presence of a 197A genotype in the recipient resulted in a higher incidence of grades II-IV acute GVHD (hazard ratio (HR), 1.87; 95% confidence interval (CI), 1.23-2.85; P=.004). The donor IL-17A genotype did not significantly influence the transplant outcomes. The validation study showed a trend toward an association of the recipient 197A genotype with an increased risk of grades III-IV acute GVHD (HR, 5.84; 95% CI, 0.75-45.72; P=.09), as well as a significantly increased risk for chronic GVHD (HR, 3.86; 95% CI, 1.29-11.59; P=.02). These results suggest an association of the 197A genotype in the recipient side with the development of acute GVHD.

Original languageEnglish
Pages (from-to)1455-1463
Number of pages9
JournalBone Marrow Transplantation
Volume46
Issue number11
DOIs
Publication statusPublished - 11-2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Hematology
  • Transplantation

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