A stable prostacyclin analogue reduces high serum TNF-α levels in diabetic patients

K. Fujiwara, A. Nagasaka, M. Nagata, K. Yamamoto, S. Imamura, N. Oda, Y. Sawai, N. Hayakawa, A. Suzuki, Mitsuyasu Itoh

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Aims: To confirm whether a prostacyclin (prostaglandin 12) affects the increased TNF-α concentration in sera of diabetic patients, we measured serum TNF-α concentration and treated these patients with oral administration of the stable prostacyclin analogue (Beraprost). Twelve of 20 type II diabetic patients were investigated for follow up-study and 6 of those patients were for therapy with Beraprost for diabetic neuropathy. Subjects and Methods: Serum TNF-α concentration was quantified by EASIA using monoclonal antibodies directed against distinct epitopes of TNF-α. Results: In diabetic patients, serum TNF-α concentration was significantly increased compared with that of healthy subjects. The augmented TNF-α concentration in these patients was not decreased by diabetic control using antihyperglycemic agents for 8 weeks but was reduced with oral administration of a stable prostacyclin (prostaglandin 12) analogue for 5 weeks without any changes of blood glucose levels. Conclusions: Stable prostacyclin analogue administration for a short term period reduced increased TNF-α levels in diabetic patients, not through the improved hyperglycemic condition but another pathway, probably a cAMP system. These results imply that treatment with the prostacyclin analogue may contribute to the prevention of progression in diabetic complications.

Original languageEnglish
Pages (from-to)390-394
Number of pages5
JournalExperimental and Clinical Endocrinology and Diabetes
Issue number7
Publication statusPublished - 01-07-2004


All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Fujiwara, K., Nagasaka, A., Nagata, M., Yamamoto, K., Imamura, S., Oda, N., Sawai, Y., Hayakawa, N., Suzuki, A., & Itoh, M. (2004). A stable prostacyclin analogue reduces high serum TNF-α levels in diabetic patients. Experimental and Clinical Endocrinology and Diabetes, 112(7), 390-394. https://doi.org/10.1055/s-2004-821024