TY - JOUR
T1 - A study of the influence of gastric acid on the extension of regenerative epithelium of gastric ulcer
AU - Wakabayashi, Takao
AU - Nakazawa, Saburo
AU - Yoshino, Junji
AU - Yamao, Kenji
AU - Inui, Kazuo
AU - Yamachika, Hitoshi
AU - Kanemaki, Naoto
AU - Fujimoto, Masao
AU - Okushima, Kazumu
AU - Watanabe, Masumi
AU - Hirano, Ken
AU - Harada, Kou
AU - Miyoshi, Hironao
AU - Taki, Norihito
AU - Sugiyama, Kazuhisa
PY - 1994
Y1 - 1994
N2 - To study the influence of gastric acid on the extension of the regenerative epithelium, 26 patients (28 ulcers) of gastric ulcer were examined by the stereo video-endoscope being able to measure the length and 24-hours intragastric pH monitoring. Extending speeds of the regenerative epithelium were measured from the time the regenerative epithelium of the ulcer was observed till the last examination, but which was limited 8 weeks after the first observation of the regenerative epithelium. The relationship was not observed between the extending speeds and the stages (A2-H1, H1-H2, H2-S1) of the ulcer. For 21 ulcers followed up by the stereo video-endoscope from active stage, the extending speed of the regenerative epithelium and the pH 3 holding time in a day were significantly correlated (r=0.51, p=0.014), and the same relationship (r=0.56, p=0.008) were observed in the nighttime. It was confirmed that the gastric acid regulated strongly the extending speed of regenerative epithelium of gastric ulcer. The intragastric circumstance of the low acid secretion induced by the antacid-drugs was considered to accelerate the extension of regenerative gastric epithelium.
AB - To study the influence of gastric acid on the extension of the regenerative epithelium, 26 patients (28 ulcers) of gastric ulcer were examined by the stereo video-endoscope being able to measure the length and 24-hours intragastric pH monitoring. Extending speeds of the regenerative epithelium were measured from the time the regenerative epithelium of the ulcer was observed till the last examination, but which was limited 8 weeks after the first observation of the regenerative epithelium. The relationship was not observed between the extending speeds and the stages (A2-H1, H1-H2, H2-S1) of the ulcer. For 21 ulcers followed up by the stereo video-endoscope from active stage, the extending speed of the regenerative epithelium and the pH 3 holding time in a day were significantly correlated (r=0.51, p=0.014), and the same relationship (r=0.56, p=0.008) were observed in the nighttime. It was confirmed that the gastric acid regulated strongly the extending speed of regenerative epithelium of gastric ulcer. The intragastric circumstance of the low acid secretion induced by the antacid-drugs was considered to accelerate the extension of regenerative gastric epithelium.
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U2 - 10.11405/nisshoshi1964.91.969
DO - 10.11405/nisshoshi1964.91.969
M3 - Article
C2 - 8196207
AN - SCOPUS:0028233012
SN - 0446-6586
VL - 91
SP - 969
EP - 975
JO - nippon shokakibyo gakkai zasshi
JF - nippon shokakibyo gakkai zasshi
IS - 5
ER -