A study of the influence of gastric acid on the extension of regenerative epithelium of gastric ulcer

Takao Wakabayashi, Saburo Nakazawa, Junji Yoshino, Kenji Yamao, Kazuo Inui, Hitoshi Yamachika, Naoto Kanemaki, Masao Fujimoto, Kazumu Okushima, Masumi Watanabe, Ken Hirano, Kou Harada, Hironao Miyoshi, Norihito Taki, Kazuhisa Sugiyama

Research output: Contribution to journalArticlepeer-review

Abstract

To study the influence of gastric acid on the extension of the regenerative epithelium, 26 patients (28 ulcers) of gastric ulcer were examined by the stereo video-endoscope being able to measure the length and 24-hours intragastric pH monitoring. Extending speeds of the regenerative epithelium were measured from the time the regenerative epithelium of the ulcer was observed till the last examination, but which was limited 8 weeks after the first observation of the regenerative epithelium. The relationship was not observed between the extending speeds and the stages (A2-H1, H1-H2, H2-S1) of the ulcer. For 21 ulcers followed up by the stereo video-endoscope from active stage, the extending speed of the regenerative epithelium and the pH 3 holding time in a day were significantly correlated (r=0.51, p=0.014), and the same relationship (r=0.56, p=0.008) were observed in the nighttime. It was confirmed that the gastric acid regulated strongly the extending speed of regenerative epithelium of gastric ulcer. The intragastric circumstance of the low acid secretion induced by the antacid-drugs was considered to accelerate the extension of regenerative gastric epithelium.

Original languageEnglish
Pages (from-to)969-975
Number of pages7
Journalnippon shokakibyo gakkai zasshi
Volume91
Issue number5
DOIs
Publication statusPublished - 1994

All Science Journal Classification (ASJC) codes

  • Gastroenterology

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