A study on the beryllium lymphocyte transformation test and the beryllium levels in working environment

Tsutomu Yoshida, Syogo Shima, Kaoru Nagaoka, Hiroshige Taniwaki, Akihiko Wada, Hideki Kurita, Kunihiko Morita

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40 Citations (Scopus)

Abstract

The relationship between airborne concentration of beryllium in the working environment and workers' beryllium lymphocyte transformation test (Be-LTT) values was examined based on data obtained from a four-year survey (1992-1995) conducted at berYllium-copper alloy manufacturing factories. This study showed that the T cells of workers continuously exposed to beryllium of more than 0.01 μg/m3 could be activated and that the cell-mediated immune response of workers could be promoted. On the other hand, the Be-LTT of workers exposed to beryllium levels of less than 0.01 μg/m3 was shown to be unaffected by beryllium. These findings suggest that beryllium sensitization is not manifested when level of beryllium in working environment are less than 0.01 μg/m3. Therefore, in such cases workers do not develop Chronic beryllium disease (CBD). We concluded that the Be-LTT can be applied as a medical indicator to detect the development of CBD.

Original languageEnglish
Pages (from-to)374-379
Number of pages6
JournalIndustrial Health
Volume35
Issue number3
DOIs
Publication statusPublished - 1997

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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