TY - JOUR
T1 - A supratentorial primitive neuroectodermal tumor in an adult
T2 - A case report and review of the literature
AU - Ohba, Shigeo
AU - Yoshida, Kazunari
AU - Hirose, Yuichi
AU - Ikeda, Eiji
AU - Kawase, Takeshi
PY - 2008/1
Y1 - 2008/1
N2 - Supratentorial primitive neuroectodermal tumors (sPNET) occurring in adults are rare. Only 56 such cases have been previously reported. This report documents a 56-year-old male who presented with the chief complaint of right facial palsy. Magnetic resonance imaging (MRI) revealed left frontal and bilateral periventricular lesions. Surgery was performed for the frontal mass, which was histologically diagnosed to be sPNET. An immunohistochemistry assay for CD99, and a fluorescence in situ hybridization (FISH) assay for t(11;22) translocation revealed this PNET to be a central PNET. This case was the first case to detect a central PNET using both immunohistochemistry and the FISH assay in adult sPNET. Though radiation therapy was performed, an MRI performed 2.5 months after the surgery revealed a regrowth of the tumor. The patient died 5 months after surgery. This case report is accompanied by a review of 57 cases of adult sPNET.
AB - Supratentorial primitive neuroectodermal tumors (sPNET) occurring in adults are rare. Only 56 such cases have been previously reported. This report documents a 56-year-old male who presented with the chief complaint of right facial palsy. Magnetic resonance imaging (MRI) revealed left frontal and bilateral periventricular lesions. Surgery was performed for the frontal mass, which was histologically diagnosed to be sPNET. An immunohistochemistry assay for CD99, and a fluorescence in situ hybridization (FISH) assay for t(11;22) translocation revealed this PNET to be a central PNET. This case was the first case to detect a central PNET using both immunohistochemistry and the FISH assay in adult sPNET. Though radiation therapy was performed, an MRI performed 2.5 months after the surgery revealed a regrowth of the tumor. The patient died 5 months after surgery. This case report is accompanied by a review of 57 cases of adult sPNET.
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U2 - 10.1007/s11060-007-9466-4
DO - 10.1007/s11060-007-9466-4
M3 - Review article
C2 - 17713720
AN - SCOPUS:37249044204
SN - 0167-594X
VL - 86
SP - 217
EP - 224
JO - Journal of Neuro-Oncology
JF - Journal of Neuro-Oncology
IS - 2
ER -
