A transient increase in serum procollagen 1 carboxyterminal peptide following effective treatment in prostate cancer patients with bone metastases

Jun Nakashima; Makoto Sumitomo; Akira Miyajima; Seido Jitsukawa; Masaru Murai

doi:10.1159/000282991

A transient increase in serum procollagen 1 carboxyterminal peptide following effective treatment in prostate cancer patients with bone metastases

Jun Nakashima, Makoto Sumitomo, Akira Miyajima, Seido Jitsukawa, Masaru Murai

Research output: Contribution to journal › Article › peer-review

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Abstract

Procollagen 1 carboxyterminal peptide (PICP) is thought to be an indicator of new bone formation. The present report demonstrates that effective endocrine therapy induced an initial increase followed by a delayed decrease in serum levels of PICP and alkaline phosphatase in spite of an immediate decrease in serum PSA and PAP and improvement of clinical symptoms in prostate cancer patients with bone metastases. The transient increase in PICP and alkaline phosphatase is a healing reaction and is followed by apparent improvement. Short-term effects of endocrine therapy on prostate cancer patients with bone metastases should be comprehensively evaluated based upon the entire spectrum of clinical and laboratory findings, including serial changes of serum prostate markers and bone markers as well.

Original language	English
Pages (from-to)	236-238
Number of pages	3
Journal	Urologia Internationalis
Volume	58
Issue number	4
DOIs	https://doi.org/10.1159/000282991
Publication status	Published - 01-01-1997
Externally published	Yes

All Science Journal Classification (ASJC) codes

Urology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000282991

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title = "A transient increase in serum procollagen 1 carboxyterminal peptide following effective treatment in prostate cancer patients with bone metastases",

abstract = "Procollagen 1 carboxyterminal peptide (PICP) is thought to be an indicator of new bone formation. The present report demonstrates that effective endocrine therapy induced an initial increase followed by a delayed decrease in serum levels of PICP and alkaline phosphatase in spite of an immediate decrease in serum PSA and PAP and improvement of clinical symptoms in prostate cancer patients with bone metastases. The transient increase in PICP and alkaline phosphatase is a healing reaction and is followed by apparent improvement. Short-term effects of endocrine therapy on prostate cancer patients with bone metastases should be comprehensively evaluated based upon the entire spectrum of clinical and laboratory findings, including serial changes of serum prostate markers and bone markers as well.",

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author = "Jun Nakashima and Makoto Sumitomo and Akira Miyajima and Seido Jitsukawa and Masaru Murai",

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T1 - A transient increase in serum procollagen 1 carboxyterminal peptide following effective treatment in prostate cancer patients with bone metastases

AU - Nakashima, Jun

AU - Sumitomo, Makoto

AU - Miyajima, Akira

AU - Jitsukawa, Seido

AU - Murai, Masaru

PY - 1997/1/1

Y1 - 1997/1/1

N2 - Procollagen 1 carboxyterminal peptide (PICP) is thought to be an indicator of new bone formation. The present report demonstrates that effective endocrine therapy induced an initial increase followed by a delayed decrease in serum levels of PICP and alkaline phosphatase in spite of an immediate decrease in serum PSA and PAP and improvement of clinical symptoms in prostate cancer patients with bone metastases. The transient increase in PICP and alkaline phosphatase is a healing reaction and is followed by apparent improvement. Short-term effects of endocrine therapy on prostate cancer patients with bone metastases should be comprehensively evaluated based upon the entire spectrum of clinical and laboratory findings, including serial changes of serum prostate markers and bone markers as well.

AB - Procollagen 1 carboxyterminal peptide (PICP) is thought to be an indicator of new bone formation. The present report demonstrates that effective endocrine therapy induced an initial increase followed by a delayed decrease in serum levels of PICP and alkaline phosphatase in spite of an immediate decrease in serum PSA and PAP and improvement of clinical symptoms in prostate cancer patients with bone metastases. The transient increase in PICP and alkaline phosphatase is a healing reaction and is followed by apparent improvement. Short-term effects of endocrine therapy on prostate cancer patients with bone metastases should be comprehensively evaluated based upon the entire spectrum of clinical and laboratory findings, including serial changes of serum prostate markers and bone markers as well.

KW - Bone metastasis

KW - Endocrine therapy

KW - PICP

KW - Prostatic neoplasms

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A transient increase in serum procollagen 1 carboxyterminal peptide following effective treatment in prostate cancer patients with bone metastases

Abstract

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