A two-stage case-control association study of the dihydropyrimidinase-like 2 gene (DPYSL2) with schizophrenia in Japanese subjects

Takayoshi Koide; Branko Aleksic; Yoshihito Ito; Hinako Usui; Akira Yoshimi; Toshiya Inada; Michio Suzuki; Ryota Hashimoto; Masatoshi Takeda; Nakao Iwata; Norio Ozaki

doi:10.1038/jhg.2010.38

A two-stage case-control association study of the dihydropyrimidinase-like 2 gene (DPYSL2) with schizophrenia in Japanese subjects

Takayoshi Koide, Branko Aleksic, Yoshihito Ito, Hinako Usui, Akira Yoshimi, Toshiya Inada, Michio Suzuki, Ryota Hashimoto, Masatoshi Takeda, Nakao Iwata, Norio Ozaki

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Abstract

We examined the association of schizophrenia (SCZ) and dihydropyrimidinase- like 2 (DPYSL2), also known as collapsin response mediator protein 2, which regulates axonal growth and branching. We genotyped 20 tag single nucleotide polymorphisms (SNPs) in 1464 patients and 1310 controls. There were two potential associations in a screening population of 384 patients and 384 controls (rs2585458: P=0.046, rs4733048: P=0.014). However, we could not replicate these associations in a confirmatory population of 1080 patients and 926 controls (rs2585458: P=0.39, rs4733048: P=0.70) or a joint analysis (rs2585458: P=0.72, rs4733048: P=0.10). We conclude that DPYSL2 does not have a major function in SCZ in Japanese subjects.

Original language	English
Pages (from-to)	469-472
Number of pages	4
Journal	Journal of Human Genetics
Volume	55
Issue number	7
DOIs	https://doi.org/10.1038/jhg.2010.38
Publication status	Published - 07-2010
Externally published	Yes

All Science Journal Classification (ASJC) codes

Genetics
Genetics(clinical)

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title = "A two-stage case-control association study of the dihydropyrimidinase-like 2 gene (DPYSL2) with schizophrenia in Japanese subjects",

abstract = "We examined the association of schizophrenia (SCZ) and dihydropyrimidinase- like 2 (DPYSL2), also known as collapsin response mediator protein 2, which regulates axonal growth and branching. We genotyped 20 tag single nucleotide polymorphisms (SNPs) in 1464 patients and 1310 controls. There were two potential associations in a screening population of 384 patients and 384 controls (rs2585458: P=0.046, rs4733048: P=0.014). However, we could not replicate these associations in a confirmatory population of 1080 patients and 926 controls (rs2585458: P=0.39, rs4733048: P=0.70) or a joint analysis (rs2585458: P=0.72, rs4733048: P=0.10). We conclude that DPYSL2 does not have a major function in SCZ in Japanese subjects.",

author = "Takayoshi Koide and Branko Aleksic and Yoshihito Ito and Hinako Usui and Akira Yoshimi and Toshiya Inada and Michio Suzuki and Ryota Hashimoto and Masatoshi Takeda and Nakao Iwata and Norio Ozaki",

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doi = "10.1038/jhg.2010.38",

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AU - Koide, Takayoshi

AU - Aleksic, Branko

AU - Ito, Yoshihito

AU - Usui, Hinako

AU - Yoshimi, Akira

AU - Inada, Toshiya

AU - Suzuki, Michio

AU - Hashimoto, Ryota

AU - Takeda, Masatoshi

AU - Iwata, Nakao

AU - Ozaki, Norio

PY - 2010/7

Y1 - 2010/7

N2 - We examined the association of schizophrenia (SCZ) and dihydropyrimidinase- like 2 (DPYSL2), also known as collapsin response mediator protein 2, which regulates axonal growth and branching. We genotyped 20 tag single nucleotide polymorphisms (SNPs) in 1464 patients and 1310 controls. There were two potential associations in a screening population of 384 patients and 384 controls (rs2585458: P=0.046, rs4733048: P=0.014). However, we could not replicate these associations in a confirmatory population of 1080 patients and 926 controls (rs2585458: P=0.39, rs4733048: P=0.70) or a joint analysis (rs2585458: P=0.72, rs4733048: P=0.10). We conclude that DPYSL2 does not have a major function in SCZ in Japanese subjects.

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A two-stage case-control association study of the dihydropyrimidinase-like 2 gene (DPYSL2) with schizophrenia in Japanese subjects

Abstract

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