Abstract
We examined the association of schizophrenia (SCZ) and dihydropyrimidinase- like 2 (DPYSL2), also known as collapsin response mediator protein 2, which regulates axonal growth and branching. We genotyped 20 tag single nucleotide polymorphisms (SNPs) in 1464 patients and 1310 controls. There were two potential associations in a screening population of 384 patients and 384 controls (rs2585458: P=0.046, rs4733048: P=0.014). However, we could not replicate these associations in a confirmatory population of 1080 patients and 926 controls (rs2585458: P=0.39, rs4733048: P=0.70) or a joint analysis (rs2585458: P=0.72, rs4733048: P=0.10). We conclude that DPYSL2 does not have a major function in SCZ in Japanese subjects.
| Original language | English |
|---|---|
| Pages (from-to) | 469-472 |
| Number of pages | 4 |
| Journal | Journal of Human Genetics |
| Volume | 55 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 01-07-2010 |
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All Science Journal Classification (ASJC) codes
- Genetics(clinical)
- Genetics
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A two-stage case-control association study of the dihydropyrimidinase-like 2 gene (DPYSL2) with schizophrenia in Japanese subjects. / Koide, Takayoshi; Aleksic, Branko; Ito, Yoshihito; Usui, Hinako; Yoshimi, Akira; Inada, Toshiya; Suzuki, Michio; Hashimoto, Ryota; Takeda, Masatoshi; Iwata, Nakao; Ozaki, Norio.
In: Journal of Human Genetics, Vol. 55, No. 7, 01.07.2010, p. 469-472.Research output: Contribution to journal › Article
TY - JOUR
T1 - A two-stage case-control association study of the dihydropyrimidinase-like 2 gene (DPYSL2) with schizophrenia in Japanese subjects
AU - Koide, Takayoshi
AU - Aleksic, Branko
AU - Ito, Yoshihito
AU - Usui, Hinako
AU - Yoshimi, Akira
AU - Inada, Toshiya
AU - Suzuki, Michio
AU - Hashimoto, Ryota
AU - Takeda, Masatoshi
AU - Iwata, Nakao
AU - Ozaki, Norio
PY - 2010/7/1
Y1 - 2010/7/1
N2 - We examined the association of schizophrenia (SCZ) and dihydropyrimidinase- like 2 (DPYSL2), also known as collapsin response mediator protein 2, which regulates axonal growth and branching. We genotyped 20 tag single nucleotide polymorphisms (SNPs) in 1464 patients and 1310 controls. There were two potential associations in a screening population of 384 patients and 384 controls (rs2585458: P=0.046, rs4733048: P=0.014). However, we could not replicate these associations in a confirmatory population of 1080 patients and 926 controls (rs2585458: P=0.39, rs4733048: P=0.70) or a joint analysis (rs2585458: P=0.72, rs4733048: P=0.10). We conclude that DPYSL2 does not have a major function in SCZ in Japanese subjects.
AB - We examined the association of schizophrenia (SCZ) and dihydropyrimidinase- like 2 (DPYSL2), also known as collapsin response mediator protein 2, which regulates axonal growth and branching. We genotyped 20 tag single nucleotide polymorphisms (SNPs) in 1464 patients and 1310 controls. There were two potential associations in a screening population of 384 patients and 384 controls (rs2585458: P=0.046, rs4733048: P=0.014). However, we could not replicate these associations in a confirmatory population of 1080 patients and 926 controls (rs2585458: P=0.39, rs4733048: P=0.70) or a joint analysis (rs2585458: P=0.72, rs4733048: P=0.10). We conclude that DPYSL2 does not have a major function in SCZ in Japanese subjects.
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U2 - 10.1038/jhg.2010.38
DO - 10.1038/jhg.2010.38
M3 - Article
VL - 55
SP - 469
EP - 472
JO - Journal of Human Genetics
JF - Journal of Human Genetics
SN - 1434-5161
IS - 7
ER -