A unique B2 B cell subset in the intestine

Yasuyo Shimomura, Atsuhiro Ogawa, Mayumi Kawada, Ken Sugimoto, Emiko Mizoguchi, Hai Ning Shi, Shiv Pillai, Atul K. Bhan, Atsushi Mizoguchi

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Over 80% of the body's activated B cells are located in mucosal sites, including the intestine. The intestine contains IgM + B cells, but these cells have not been characterized phenotypically or in terms of their developmental origins. We describe a previously unidentified and unique subset of immunoglobulin M + B cells that present with an AA4.1 - CD21 - CD23 - major histocompatibility complex class II bright surface phenotype and are characterized by a low frequency of somatic hypermutation and the potential ability to produce interleukin-12p70. This B cell subset resides within the normal mucosa of the large intestine and expands in response to inflammation. Some of these intestinal B cells originate from the AA4.1 + immature B2 cell pool in the steady state and are also recruited from the recirculating naive B cell pool in the context of intestinal inflammation. They develop in an antigen-independent and BAFF-dependent manner in the absence of T cell help. Expansion of these cells can be induced in the absence of the spleen and gut-associated lymphoid tissues. These results describe the existence of an alternative pathway of B cell maturation in the periphery that gives rise to a tissue-specific B cell subset.

Original languageEnglish
Pages (from-to)1343-1355
Number of pages13
JournalJournal of Experimental Medicine
Volume205
Issue number6
DOIs
Publication statusPublished - 09-06-2008
Externally publishedYes

Fingerprint

B-Lymphocyte Subsets
Intestines
B-Lymphocytes
Immunoglobulin M
Inflammation
Interleukins
Large Intestine
Lymphoid Tissue
Major Histocompatibility Complex
Mucous Membrane
Spleen
T-Lymphocytes
Phenotype
Antigens

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Shimomura, Y., Ogawa, A., Kawada, M., Sugimoto, K., Mizoguchi, E., Shi, H. N., ... Mizoguchi, A. (2008). A unique B2 B cell subset in the intestine. Journal of Experimental Medicine, 205(6), 1343-1355. https://doi.org/10.1084/jem.20071572
Shimomura, Yasuyo ; Ogawa, Atsuhiro ; Kawada, Mayumi ; Sugimoto, Ken ; Mizoguchi, Emiko ; Shi, Hai Ning ; Pillai, Shiv ; Bhan, Atul K. ; Mizoguchi, Atsushi. / A unique B2 B cell subset in the intestine. In: Journal of Experimental Medicine. 2008 ; Vol. 205, No. 6. pp. 1343-1355.
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Shimomura, Y, Ogawa, A, Kawada, M, Sugimoto, K, Mizoguchi, E, Shi, HN, Pillai, S, Bhan, AK & Mizoguchi, A 2008, 'A unique B2 B cell subset in the intestine', Journal of Experimental Medicine, vol. 205, no. 6, pp. 1343-1355. https://doi.org/10.1084/jem.20071572

A unique B2 B cell subset in the intestine. / Shimomura, Yasuyo; Ogawa, Atsuhiro; Kawada, Mayumi; Sugimoto, Ken; Mizoguchi, Emiko; Shi, Hai Ning; Pillai, Shiv; Bhan, Atul K.; Mizoguchi, Atsushi.

In: Journal of Experimental Medicine, Vol. 205, No. 6, 09.06.2008, p. 1343-1355.

Research output: Contribution to journalArticle

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Shimomura Y, Ogawa A, Kawada M, Sugimoto K, Mizoguchi E, Shi HN et al. A unique B2 B cell subset in the intestine. Journal of Experimental Medicine. 2008 Jun 9;205(6):1343-1355. https://doi.org/10.1084/jem.20071572