Abstract
Converging evidence in neurophysiological and neuroimaging studies has suggested that the limbic and prefrontal systems play important roles in emotion and cognition. These structures are activated when we see a human face, assuming that we automatically evaluate the biological significance of the stimuli. The serotonin (5-HT) system within the brain has been tied to various behaviors such as mood and anxiety and to the biology of neuropsychiatric disorders. To investigate the link between the 5-HT system and limbic/prefrontal activity, normal subjects (n = 26) who underwent functional magnetic resonance imaging and faced recognition tasks were genotyped for the single nucleotide polymorphism C178T in the regulatory region of the serotonin receptor type 3 gene (HTR3A). We found that the subjects with C/C alleles had greater activity in the amygdala and dorsal and medial prefrontal cortices than those with C/T alleles. The C/C group also showed a faster reaction time during the task than the C/T group. The temperamental predisposition of the subjects had a significant correlation with brain activity in the C/C group. The genotype effect in the right amygdala and prefrontal cortex was largest during the first run of the experiment. These results indicate that the C178T variation in the HTR3A has a critical influence on the amygdaloid activity and on human face processing, probably through regulation of the receptor expression. The present study may contribute to elucidating a possible link among genes, the brain, and behavior in normal populations and may help reveal the biological basis of neuropsychiatric disorders.
| Original language | English |
|---|---|
| Pages (from-to) | 6460-6466 |
| Number of pages | 7 |
| Journal | Journal of Neuroscience |
| Volume | 25 |
| Issue number | 27 |
| DOIs | |
| Publication status | Published - 06-07-2005 |
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All Science Journal Classification (ASJC) codes
- Neuroscience(all)
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A variant C178T in the regulatory region of the serotonin receptor gene HTR3A modulates neural activation in the human amygdala. / Iidaka, Tetsuya; Ozaki, Norio; Matsumoto, Atsushi; Nogawa, Junpei; Kinoshita, Yoko; Suzuki, Tatsuyo; Iwata, Nakao; Yamamoto, Yukiko; Okada, Tomohisa; Sadato, Norihiro.
In: Journal of Neuroscience, Vol. 25, No. 27, 06.07.2005, p. 6460-6466.Research output: Contribution to journal › Article
TY - JOUR
T1 - A variant C178T in the regulatory region of the serotonin receptor gene HTR3A modulates neural activation in the human amygdala
AU - Iidaka, Tetsuya
AU - Ozaki, Norio
AU - Matsumoto, Atsushi
AU - Nogawa, Junpei
AU - Kinoshita, Yoko
AU - Suzuki, Tatsuyo
AU - Iwata, Nakao
AU - Yamamoto, Yukiko
AU - Okada, Tomohisa
AU - Sadato, Norihiro
PY - 2005/7/6
Y1 - 2005/7/6
N2 - Converging evidence in neurophysiological and neuroimaging studies has suggested that the limbic and prefrontal systems play important roles in emotion and cognition. These structures are activated when we see a human face, assuming that we automatically evaluate the biological significance of the stimuli. The serotonin (5-HT) system within the brain has been tied to various behaviors such as mood and anxiety and to the biology of neuropsychiatric disorders. To investigate the link between the 5-HT system and limbic/prefrontal activity, normal subjects (n = 26) who underwent functional magnetic resonance imaging and faced recognition tasks were genotyped for the single nucleotide polymorphism C178T in the regulatory region of the serotonin receptor type 3 gene (HTR3A). We found that the subjects with C/C alleles had greater activity in the amygdala and dorsal and medial prefrontal cortices than those with C/T alleles. The C/C group also showed a faster reaction time during the task than the C/T group. The temperamental predisposition of the subjects had a significant correlation with brain activity in the C/C group. The genotype effect in the right amygdala and prefrontal cortex was largest during the first run of the experiment. These results indicate that the C178T variation in the HTR3A has a critical influence on the amygdaloid activity and on human face processing, probably through regulation of the receptor expression. The present study may contribute to elucidating a possible link among genes, the brain, and behavior in normal populations and may help reveal the biological basis of neuropsychiatric disorders.
AB - Converging evidence in neurophysiological and neuroimaging studies has suggested that the limbic and prefrontal systems play important roles in emotion and cognition. These structures are activated when we see a human face, assuming that we automatically evaluate the biological significance of the stimuli. The serotonin (5-HT) system within the brain has been tied to various behaviors such as mood and anxiety and to the biology of neuropsychiatric disorders. To investigate the link between the 5-HT system and limbic/prefrontal activity, normal subjects (n = 26) who underwent functional magnetic resonance imaging and faced recognition tasks were genotyped for the single nucleotide polymorphism C178T in the regulatory region of the serotonin receptor type 3 gene (HTR3A). We found that the subjects with C/C alleles had greater activity in the amygdala and dorsal and medial prefrontal cortices than those with C/T alleles. The C/C group also showed a faster reaction time during the task than the C/T group. The temperamental predisposition of the subjects had a significant correlation with brain activity in the C/C group. The genotype effect in the right amygdala and prefrontal cortex was largest during the first run of the experiment. These results indicate that the C178T variation in the HTR3A has a critical influence on the amygdaloid activity and on human face processing, probably through regulation of the receptor expression. The present study may contribute to elucidating a possible link among genes, the brain, and behavior in normal populations and may help reveal the biological basis of neuropsychiatric disorders.
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UR - http://www.scopus.com/inward/citedby.url?scp=22044431993&partnerID=8YFLogxK
U2 - 10.1523/JNEUROSCI.5261-04.2005
DO - 10.1523/JNEUROSCI.5261-04.2005
M3 - Article
C2 - 16000636
AN - SCOPUS:22044431993
VL - 25
SP - 6460
EP - 6466
JO - Journal of Neuroscience
JF - Journal of Neuroscience
SN - 0270-6474
IS - 27
ER -