A variant C178T in the regulatory region of the serotonin receptor gene HTR3A modulates neural activation in the human amygdala

Tetsuya Iidaka, Norio Ozaki, Atsushi Matsumoto, Junpei Nogawa, Yoko Kinoshita, Tatsuyo Suzuki, Nakao Iwata, Yukiko Yamamoto, Tomohisa Okada, Norihiro Sadato

Research output: Contribution to journalArticle

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Abstract

Converging evidence in neurophysiological and neuroimaging studies has suggested that the limbic and prefrontal systems play important roles in emotion and cognition. These structures are activated when we see a human face, assuming that we automatically evaluate the biological significance of the stimuli. The serotonin (5-HT) system within the brain has been tied to various behaviors such as mood and anxiety and to the biology of neuropsychiatric disorders. To investigate the link between the 5-HT system and limbic/prefrontal activity, normal subjects (n = 26) who underwent functional magnetic resonance imaging and faced recognition tasks were genotyped for the single nucleotide polymorphism C178T in the regulatory region of the serotonin receptor type 3 gene (HTR3A). We found that the subjects with C/C alleles had greater activity in the amygdala and dorsal and medial prefrontal cortices than those with C/T alleles. The C/C group also showed a faster reaction time during the task than the C/T group. The temperamental predisposition of the subjects had a significant correlation with brain activity in the C/C group. The genotype effect in the right amygdala and prefrontal cortex was largest during the first run of the experiment. These results indicate that the C178T variation in the HTR3A has a critical influence on the amygdaloid activity and on human face processing, probably through regulation of the receptor expression. The present study may contribute to elucidating a possible link among genes, the brain, and behavior in normal populations and may help reveal the biological basis of neuropsychiatric disorders.

Original languageEnglish
Pages (from-to)6460-6466
Number of pages7
JournalJournal of Neuroscience
Volume25
Issue number27
DOIs
Publication statusPublished - 06-07-2005

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Serotonin Receptors
Nucleic Acid Regulatory Sequences
Amygdala
Serotonin
Limbic System
Prefrontal Cortex
Brain
Alleles
Genes
Receptors, Serotonin, 5-HT3
Human Activities
Neuroimaging
Cognition
Reaction Time
Single Nucleotide Polymorphism
Emotions
Anxiety
Genotype
Magnetic Resonance Imaging
Population

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Iidaka, Tetsuya ; Ozaki, Norio ; Matsumoto, Atsushi ; Nogawa, Junpei ; Kinoshita, Yoko ; Suzuki, Tatsuyo ; Iwata, Nakao ; Yamamoto, Yukiko ; Okada, Tomohisa ; Sadato, Norihiro. / A variant C178T in the regulatory region of the serotonin receptor gene HTR3A modulates neural activation in the human amygdala. In: Journal of Neuroscience. 2005 ; Vol. 25, No. 27. pp. 6460-6466.
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Iidaka, T, Ozaki, N, Matsumoto, A, Nogawa, J, Kinoshita, Y, Suzuki, T, Iwata, N, Yamamoto, Y, Okada, T & Sadato, N 2005, 'A variant C178T in the regulatory region of the serotonin receptor gene HTR3A modulates neural activation in the human amygdala', Journal of Neuroscience, vol. 25, no. 27, pp. 6460-6466. https://doi.org/10.1523/JNEUROSCI.5261-04.2005

A variant C178T in the regulatory region of the serotonin receptor gene HTR3A modulates neural activation in the human amygdala. / Iidaka, Tetsuya; Ozaki, Norio; Matsumoto, Atsushi; Nogawa, Junpei; Kinoshita, Yoko; Suzuki, Tatsuyo; Iwata, Nakao; Yamamoto, Yukiko; Okada, Tomohisa; Sadato, Norihiro.

In: Journal of Neuroscience, Vol. 25, No. 27, 06.07.2005, p. 6460-6466.

Research output: Contribution to journalArticle

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T1 - A variant C178T in the regulatory region of the serotonin receptor gene HTR3A modulates neural activation in the human amygdala

AU - Iidaka, Tetsuya

AU - Ozaki, Norio

AU - Matsumoto, Atsushi

AU - Nogawa, Junpei

AU - Kinoshita, Yoko

AU - Suzuki, Tatsuyo

AU - Iwata, Nakao

AU - Yamamoto, Yukiko

AU - Okada, Tomohisa

AU - Sadato, Norihiro

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