ABCG2 is a high-capacity urate transporter and its genetic impairment increases serum uric acid levels in humans

Akiyoshi Nakayama; Hirotaka Matsuo; Tappei Takada; Kimiyoshi Ichida; Takahiro Nakamura; Yuki Ikebuchi; Kousei Ito; Tatsuo Hosoya; Yoshikatsu Kanai; Hiroshi Suzuki; Nariyoshi Shinomiya

doi:10.1080/15257770.2011.633953

ABCG2 is a high-capacity urate transporter and its genetic impairment increases serum uric acid levels in humans

Akiyoshi Nakayama
, Hirotaka Matsuo
, Tappei Takada
, Kimiyoshi Ichida
, Takahiro Nakamura
, Yuki Ikebuchi
, Kousei Ito
, Tatsuo Hosoya
, Yoshikatsu Kanai
, Hiroshi Suzuki
, Nariyoshi Shinomiya

Research output: Contribution to journal › Article › peer-review

73 Citations (Scopus)

Abstract

The ATP-binding cassette, subfamily G, member 2 (ABCG2/BCRP) gene encodes a well-known transporter, which exports various substrates including nucleotide analogs such as 3'-azido-3' - deoxythymidine (AZT). ABCG2 is also located in a gout-susceptibility locus (MIM 138900) on chromosome 4q, and has recently been identified by genome-wide association studies to relate to serum uric acid (SUA) and gout. Becuase urate is structurally similar to nucleotide analogs, we hypothesized that ABCG2 might be a urate exporter. To demonstrate our hypothesis, transport assays were performed with membrane vesicles prepared from ABCG2-overexpressing cells. Transport of

Original language	English
Pages (from-to)	1091-1097
Number of pages	7
Journal	Nucleosides, Nucleotides and Nucleic Acids
Volume	30
Issue number	12
DOIs	https://doi.org/10.1080/15257770.2011.633953
Publication status	Published - 2011
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Genetics

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10.1080/15257770.2011.633953

Cite this

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abstract = "The ATP-binding cassette, subfamily G, member 2 (ABCG2/BCRP) gene encodes a well-known transporter, which exports various substrates including nucleotide analogs such as 3'-azido-3' - deoxythymidine (AZT). ABCG2 is also located in a gout-susceptibility locus (MIM 138900) on chromosome 4q, and has recently been identified by genome-wide association studies to relate to serum uric acid (SUA) and gout. Becuase urate is structurally similar to nucleotide analogs, we hypothesized that ABCG2 might be a urate exporter. To demonstrate our hypothesis, transport assays were performed with membrane vesicles prepared from ABCG2-overexpressing cells. Transport of",

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AU - Nakayama, Akiyoshi

AU - Matsuo, Hirotaka

AU - Takada, Tappei

AU - Ichida, Kimiyoshi

AU - Nakamura, Takahiro

AU - Ikebuchi, Yuki

AU - Ito, Kousei

AU - Hosoya, Tatsuo

AU - Kanai, Yoshikatsu

AU - Suzuki, Hiroshi

AU - Shinomiya, Nariyoshi

PY - 2011

Y1 - 2011

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ABCG2 is a high-capacity urate transporter and its genetic impairment increases serum uric acid levels in humans

Abstract

All Science Journal Classification (ASJC) codes

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