TY - JOUR
T1 - ABCG2 is a high-capacity urate transporter and its genetic impairment increases serum uric acid levels in humans
AU - Nakayama, Akiyoshi
AU - Matsuo, Hirotaka
AU - Takada, Tappei
AU - Ichida, Kimiyoshi
AU - Nakamura, Takahiro
AU - Ikebuchi, Yuki
AU - Ito, Kousei
AU - Hosoya, Tatsuo
AU - Kanai, Yoshikatsu
AU - Suzuki, Hiroshi
AU - Shinomiya, Nariyoshi
PY - 2011
Y1 - 2011
N2 - The ATP-binding cassette, subfamily G, member 2 (ABCG2/BCRP) gene encodes a well-known transporter, which exports various substrates including nucleotide analogs such as 3'-azido-3' - deoxythymidine (AZT). ABCG2 is also located in a gout-susceptibility locus (MIM 138900) on chromosome 4q, and has recently been identified by genome-wide association studies to relate to serum uric acid (SUA) and gout. Becuase urate is structurally similar to nucleotide analogs, we hypothesized that ABCG2 might be a urate exporter. To demonstrate our hypothesis, transport assays were performed with membrane vesicles prepared from ABCG2-overexpressing cells. Transport of
AB - The ATP-binding cassette, subfamily G, member 2 (ABCG2/BCRP) gene encodes a well-known transporter, which exports various substrates including nucleotide analogs such as 3'-azido-3' - deoxythymidine (AZT). ABCG2 is also located in a gout-susceptibility locus (MIM 138900) on chromosome 4q, and has recently been identified by genome-wide association studies to relate to serum uric acid (SUA) and gout. Becuase urate is structurally similar to nucleotide analogs, we hypothesized that ABCG2 might be a urate exporter. To demonstrate our hypothesis, transport assays were performed with membrane vesicles prepared from ABCG2-overexpressing cells. Transport of
UR - https://www.scopus.com/pages/publications/84862969715
UR - https://www.scopus.com/pages/publications/84862969715#tab=citedBy
U2 - 10.1080/15257770.2011.633953
DO - 10.1080/15257770.2011.633953
M3 - Article
C2 - 22132962
AN - SCOPUS:84862969715
SN - 1525-7770
VL - 30
SP - 1091
EP - 1097
JO - Nucleosides, Nucleotides and Nucleic Acids
JF - Nucleosides, Nucleotides and Nucleic Acids
IS - 12
ER -