Aberrant DNA replication in cancer

Motoshi Suzuki, Takashi Takahashi

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Genomic instability plays an important role in cancer susceptibility, though the mechanics of its development remain unclear. An often-stated hypothesis is that error-prone phenotypes in DNA replication or aberrations in translesion DNA synthesis lead to genomic instability and cancer. Mutations in core DNA replication proteins have been identified in human cancer, although DNA replication is essential for cell proliferation and most mutations eliminating this function are deleterious. With recent developments in this field we review and discuss the possible involvement of DNA replication proteins in carcinogenesis.

Original languageEnglish
Pages (from-to)111-117
Number of pages7
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume743-744
DOIs
Publication statusPublished - 01-03-2013
Externally publishedYes

Fingerprint

DNA Replication
Genomic Instability
Neoplasms
Mutation
Mechanics
Carcinogenesis
Proteins
Cell Proliferation
Phenotype
DNA

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Health, Toxicology and Mutagenesis

Cite this

@article{792a7bdb65f04f16a02efd4c8b381d1d,
title = "Aberrant DNA replication in cancer",
abstract = "Genomic instability plays an important role in cancer susceptibility, though the mechanics of its development remain unclear. An often-stated hypothesis is that error-prone phenotypes in DNA replication or aberrations in translesion DNA synthesis lead to genomic instability and cancer. Mutations in core DNA replication proteins have been identified in human cancer, although DNA replication is essential for cell proliferation and most mutations eliminating this function are deleterious. With recent developments in this field we review and discuss the possible involvement of DNA replication proteins in carcinogenesis.",
author = "Motoshi Suzuki and Takashi Takahashi",
year = "2013",
month = "3",
day = "1",
doi = "10.1016/j.mrfmmm.2012.07.003",
language = "English",
volume = "743-744",
pages = "111--117",
journal = "Mutation Research",
issn = "1386-1964",
publisher = "Elsevier BV",

}

Aberrant DNA replication in cancer. / Suzuki, Motoshi; Takahashi, Takashi.

In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 743-744, 01.03.2013, p. 111-117.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Aberrant DNA replication in cancer

AU - Suzuki, Motoshi

AU - Takahashi, Takashi

PY - 2013/3/1

Y1 - 2013/3/1

N2 - Genomic instability plays an important role in cancer susceptibility, though the mechanics of its development remain unclear. An often-stated hypothesis is that error-prone phenotypes in DNA replication or aberrations in translesion DNA synthesis lead to genomic instability and cancer. Mutations in core DNA replication proteins have been identified in human cancer, although DNA replication is essential for cell proliferation and most mutations eliminating this function are deleterious. With recent developments in this field we review and discuss the possible involvement of DNA replication proteins in carcinogenesis.

AB - Genomic instability plays an important role in cancer susceptibility, though the mechanics of its development remain unclear. An often-stated hypothesis is that error-prone phenotypes in DNA replication or aberrations in translesion DNA synthesis lead to genomic instability and cancer. Mutations in core DNA replication proteins have been identified in human cancer, although DNA replication is essential for cell proliferation and most mutations eliminating this function are deleterious. With recent developments in this field we review and discuss the possible involvement of DNA replication proteins in carcinogenesis.

UR - http://www.scopus.com/inward/record.url?scp=84877924200&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84877924200&partnerID=8YFLogxK

U2 - 10.1016/j.mrfmmm.2012.07.003

DO - 10.1016/j.mrfmmm.2012.07.003

M3 - Review article

C2 - 22968031

AN - SCOPUS:84877924200

VL - 743-744

SP - 111

EP - 117

JO - Mutation Research

JF - Mutation Research

SN - 1386-1964

ER -