Aberrant DNA replication in cancer

Motoshi Suzuki; Takashi Takahashi

doi:10.1016/j.mrfmmm.2012.07.003

Aberrant DNA replication in cancer

Motoshi Suzuki
, Takashi Takahashi

Research output: Contribution to journal › Review article › peer-review

22 Citations (Scopus)

Abstract

Genomic instability plays an important role in cancer susceptibility, though the mechanics of its development remain unclear. An often-stated hypothesis is that error-prone phenotypes in DNA replication or aberrations in translesion DNA synthesis lead to genomic instability and cancer. Mutations in core DNA replication proteins have been identified in human cancer, although DNA replication is essential for cell proliferation and most mutations eliminating this function are deleterious. With recent developments in this field we review and discuss the possible involvement of DNA replication proteins in carcinogenesis.

Original language	English
Pages (from-to)	111-117
Number of pages	7
Journal	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume	743-744
DOIs	https://doi.org/10.1016/j.mrfmmm.2012.07.003
Publication status	Published - 03-2013
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Molecular Biology
Genetics
Health, Toxicology and Mutagenesis

Access to Document

10.1016/j.mrfmmm.2012.07.003

Cite this

@article{792a7bdb65f04f16a02efd4c8b381d1d,

title = "Aberrant DNA replication in cancer",

abstract = "Genomic instability plays an important role in cancer susceptibility, though the mechanics of its development remain unclear. An often-stated hypothesis is that error-prone phenotypes in DNA replication or aberrations in translesion DNA synthesis lead to genomic instability and cancer. Mutations in core DNA replication proteins have been identified in human cancer, although DNA replication is essential for cell proliferation and most mutations eliminating this function are deleterious. With recent developments in this field we review and discuss the possible involvement of DNA replication proteins in carcinogenesis.",

author = "Motoshi Suzuki and Takashi Takahashi",

note = "Funding Information: We thank Drs. Adonis Skandalis at Brock University and Yuji Masuda at Nagoya University for critical reading of this manuscript. This work was supported in part by a Grant-in-Aid for Scientific Research on Innovative Areas from the Ministry of Education, Culture, Sports, Science, and Technology of Japan , and a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science .",

year = "2013",

month = mar,

doi = "10.1016/j.mrfmmm.2012.07.003",

language = "English",

volume = "743-744",

pages = "111--117",

journal = "Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis",

issn = "0027-5107",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Aberrant DNA replication in cancer

AU - Suzuki, Motoshi

AU - Takahashi, Takashi

N1 - Funding Information: We thank Drs. Adonis Skandalis at Brock University and Yuji Masuda at Nagoya University for critical reading of this manuscript. This work was supported in part by a Grant-in-Aid for Scientific Research on Innovative Areas from the Ministry of Education, Culture, Sports, Science, and Technology of Japan , and a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science .

PY - 2013/3

Y1 - 2013/3

N2 - Genomic instability plays an important role in cancer susceptibility, though the mechanics of its development remain unclear. An often-stated hypothesis is that error-prone phenotypes in DNA replication or aberrations in translesion DNA synthesis lead to genomic instability and cancer. Mutations in core DNA replication proteins have been identified in human cancer, although DNA replication is essential for cell proliferation and most mutations eliminating this function are deleterious. With recent developments in this field we review and discuss the possible involvement of DNA replication proteins in carcinogenesis.

AB - Genomic instability plays an important role in cancer susceptibility, though the mechanics of its development remain unclear. An often-stated hypothesis is that error-prone phenotypes in DNA replication or aberrations in translesion DNA synthesis lead to genomic instability and cancer. Mutations in core DNA replication proteins have been identified in human cancer, although DNA replication is essential for cell proliferation and most mutations eliminating this function are deleterious. With recent developments in this field we review and discuss the possible involvement of DNA replication proteins in carcinogenesis.

UR - https://www.scopus.com/pages/publications/84877924200

UR - https://www.scopus.com/pages/publications/84877924200#tab=citedBy

U2 - 10.1016/j.mrfmmm.2012.07.003

DO - 10.1016/j.mrfmmm.2012.07.003

M3 - Review article

C2 - 22968031

AN - SCOPUS:84877924200

SN - 0027-5107

VL - 743-744

SP - 111

EP - 117

JO - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

JF - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

ER -

Aberrant DNA replication in cancer

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this