Abnormalities in extracellular glycine and glutamate levels in the striatum of sandy mice

Yuji Kitaichi, Ryota Hashimoto, Takeshi Inoue, Tomohiro Abekawa, Aya Kakuta, Satoko Hattori, Tsukasa Koyama

Research output: Contribution to journalArticle

Abstract

Objective Glycine regulates glutamatergic neurotransmission, and several papers have reported the relationship between glycine and schizophrenia. The dysbindin-1 (DTNBP1: dystrobrevin-binding protein 1) gene is related to glutamatergic neurotransmission and has been found to be a strong candidate gene for schizophrenia. In this study, we clarified the relationship between dysbindin, glutamate, and glycine with in vivo microdialysis methods. Methods We measured extracellular glycine and glutamate levels in the striatum of sandy (sdy) mice using in vivo microdialysis methods. Sdy mice express no dysbindin protein owing to a deletion in the dysbindin-1 gene. In addition, we measured changes in those amino acids after methamphetamine (METH) administration. Results The basal levels of extracellular glycine and glutamate in the striatum of sdy mice were elevated. These extracellular glutamate levels decreased gradually after METH administration and were not subsequently different from those of wild-type mice. Conclusions These results suggest that dysbindin might modulate glycine and glutamate release in vivo.

Original languageEnglish
Pages (from-to)215-220
Number of pages6
JournalActa Neuropsychiatrica
Volume25
Issue number4
DOIs
Publication statusPublished - 08-2013

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

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    Kitaichi, Y., Hashimoto, R., Inoue, T., Abekawa, T., Kakuta, A., Hattori, S., & Koyama, T. (2013). Abnormalities in extracellular glycine and glutamate levels in the striatum of sandy mice. Acta Neuropsychiatrica, 25(4), 215-220. https://doi.org/10.1111/acn.12018