Abnormalities in the upper gastrointestinal tract in inflammatory bowel disease

T. Ando, K. Nobata, O. Watanabe, K. Kusugami, O. Maeda, K. Ishiguro, N. Ohmiya, Y. Niwa, H. Goto

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

The predominant histopathologic feature of inflammatory bowel disease is the infiltration of acute and chronic inflammatory cells, including polymorphonuclear neutrophils, macrophages and lymphocytes, in the affected intestine. Helicobacter pylori is recognized as the most common cause of upper gastrointestinal lesions, and Helicobacter pylori-associated gastritis is characterized by increased numbers of acute and chronic inflammatory cells. The pathogenesis of inflammatory bowel disease or Helicobacter pylori-associated gastritis involves immunological abnormalities, including the deficient or excessive expression of cytokines. The chronic inflammatory process in patients with Crohn's disease may affect any part of the gastrointestinal tract, whereas ulcerative colitis affects mainly the colon and rectum. Here, we discuss abnormalities in the upper gastrointestinal tract in inflammatory bowel disease. Although the prevalence rate of Helicobacter pylori infection is low in Crohn's disease, these patients often have abnormalities in the upper gastrointestinal tract.

Original languageEnglish
Pages (from-to)101-104
Number of pages4
JournalInflammopharmacology
Volume15
Issue number3
DOIs
Publication statusPublished - 06-2007

All Science Journal Classification (ASJC) codes

  • Immunology
  • Pharmacology
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Abnormalities in the upper gastrointestinal tract in inflammatory bowel disease'. Together they form a unique fingerprint.

  • Cite this

    Ando, T., Nobata, K., Watanabe, O., Kusugami, K., Maeda, O., Ishiguro, K., Ohmiya, N., Niwa, Y., & Goto, H. (2007). Abnormalities in the upper gastrointestinal tract in inflammatory bowel disease. Inflammopharmacology, 15(3), 101-104. https://doi.org/10.1007/s10787-006-0735-1