Abnormalities of sensory and memory functions in mice lacking Bsg gene

Kazumasa Naruhashi, Kenji Kadomatsu, Tadahiko Igakura, Qi Wen Fan, Naohiko Kuno, Hisako Muramatsu, Teruo Miyauchi, Takaaki Hasegawa, Akio Itoh, Takashi Muramatsu, Toshitaka Nabeshima

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Basigin is a highly glycosylated transmembrane protein belonging to the immunoglobulin superfamily. We used mutant mice lacking the basigin gene (Bsg) to investigate its involvement in learning and memory. Mutations were generated by the gene targeting method. Various kinds of learning and memory tasks were performed in mutant, hetero and wild type mice. The mutant mice showed worse performance than the wild and hetero mice in the Y-maze task, which assesses short-term memory, and in the water finding task, which examines latent learning, without any motor dysfunction. Moreover, the mutant mice showed less acclimation in the habituation task compared with the wild-type mice. The mutant mice were also more sensitive to electric foot-shock. These findings are consistent with the expression profile of basigin in the central nervous system. Thus, basigin may play an important role in learning and memory as well as in the sensory functions.

Original languageEnglish
Pages (from-to)733-737
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume236
Issue number3
DOIs
Publication statusPublished - 30-07-1997
Externally publishedYes

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CD147 Antigens
Genes
Data storage equipment
Learning
Neurology
Immunoglobulins
Gene Targeting
Acclimatization
Water
Short-Term Memory
Foot
Shock
Central Nervous System
Proteins
Mutation

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Naruhashi, Kazumasa ; Kadomatsu, Kenji ; Igakura, Tadahiko ; Fan, Qi Wen ; Kuno, Naohiko ; Muramatsu, Hisako ; Miyauchi, Teruo ; Hasegawa, Takaaki ; Itoh, Akio ; Muramatsu, Takashi ; Nabeshima, Toshitaka. / Abnormalities of sensory and memory functions in mice lacking Bsg gene. In: Biochemical and Biophysical Research Communications. 1997 ; Vol. 236, No. 3. pp. 733-737.
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Naruhashi, K, Kadomatsu, K, Igakura, T, Fan, QW, Kuno, N, Muramatsu, H, Miyauchi, T, Hasegawa, T, Itoh, A, Muramatsu, T & Nabeshima, T 1997, 'Abnormalities of sensory and memory functions in mice lacking Bsg gene', Biochemical and Biophysical Research Communications, vol. 236, no. 3, pp. 733-737. https://doi.org/10.1006/bbrc.1997.6993

Abnormalities of sensory and memory functions in mice lacking Bsg gene. / Naruhashi, Kazumasa; Kadomatsu, Kenji; Igakura, Tadahiko; Fan, Qi Wen; Kuno, Naohiko; Muramatsu, Hisako; Miyauchi, Teruo; Hasegawa, Takaaki; Itoh, Akio; Muramatsu, Takashi; Nabeshima, Toshitaka.

In: Biochemical and Biophysical Research Communications, Vol. 236, No. 3, 30.07.1997, p. 733-737.

Research output: Contribution to journalArticle

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