ABO Incompatibility

Duck J. Han, Takashi Kenmochi

Research output: Chapter in Book/Report/Conference proceedingChapter


In organ transplantation, ABO incompatibility has been a hurdle to successful living donor (LD) transplantation. However, over the past two decades, significant progress has been made in this field. Pretransplant desensitization, primarily with plasmapheresis and rituximab, has opened a new horizon and has led to predictable graft survival (GS) similar to ABO-compatible transplants not only in kidney but also in liver transplantation. In pancreas transplantation, ABO-incompatible living donor transplants are rarely performed. Following the encouraging results with ABO-incompatible kidney transplantation, this experience can also be applied to pancreas transplantation from LDs, particularly if a human leukocyte antigen-identical donor is available or if the potential recipient is (highly) sensitized. In this chapter, we report on the ABO-incompatible LD pancreas transplant experience in Asian countries with a focus on Japan and Korea, where deceased donor pancreas transplantation remains uncommon. Overall results with ABO-incompatible LD transplants have been favorable using effective preconditioning and immunosuppressive regimens.

Original languageEnglish
Title of host publicationTransplantation of the Pancreas
Subtitle of host publicationSecond Edition
PublisherSpringer International Publishing
Number of pages20
ISBN (Electronic)9783031209994
ISBN (Print)9783031209987
Publication statusPublished - 01-01-2023
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Medicine


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