ABO Incompatibility

Duck J. Han, Takashi Kenmochi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In organ transplantation, ABO incompatibility has been a hurdle to successful living donor (LD) transplantation. However, over the past two decades, significant progress has been made in this field. Pretransplant desensitization, primarily with plasmapheresis and rituximab, has opened a new horizon and has led to predictable graft survival (GS) similar to ABO-compatible transplants not only in kidney but also in liver transplantation. In pancreas transplantation, ABO-incompatible living donor transplants are rarely performed. Following the encouraging results with ABO-incompatible kidney transplantation, this experience can also be applied to pancreas transplantation from LDs, particularly if a human leukocyte antigen-identical donor is available or if the potential recipient is (highly) sensitized. In this chapter, we report on the ABO-incompatible LD pancreas transplant experience in Asian countries with a focus on Japan and Korea, where deceased donor pancreas transplantation remains uncommon. Overall results with ABO-incompatible LD transplants have been favorable using effective preconditioning and immunosuppressive regimens.

Original languageEnglish
Title of host publicationTransplantation of the Pancreas
Subtitle of host publicationSecond Edition
PublisherSpringer International Publishing
Pages735-754
Number of pages20
ISBN (Electronic)9783031209994
ISBN (Print)9783031209987
DOIs
Publication statusPublished - 01-01-2023
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Medicine

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